Qiu Jinchun, Guo Hongli, Li Ling, Xu Zeyue, Xu Zejun, Jing Xia, Hu Yahui, Wen Xiaoyi, Chen Feng, Lu Xiaopeng
Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China.
School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China.
J Biomed Res. 2020 Nov 20;35(1):61-67. doi: 10.7555/JBR.34.20200057.
To evaluate if valproic acid (VPA) therapy is associated with vitamin D deficiency among infants and toddlers with epilepsy, a cross-sectional clinical study was conducted in 25 children with epilepsy taking VPA. Blood levels of calcium, phosphorus, alkaline phosphatase, and 25-hydroxy vitamin D [25(OH)D] and plasma VPA level were measured at 1- to 3-month intervals. At the initial and final measurements, vitamin D deficiency or insufficiency was recognized in 8 (32%) and 12 (42%), respectively. In girls, a decreasing trend in serum 25(OH)D levels ( <0.05) was observed. Polytherapy had a significant negative effect on the longitudinal change of 25(OH)D ( <0.05) in girls. In conclusion, our study indicates that a high proportion of girls after VPA therapy had hypovitaminosis D.
为评估丙戊酸（VPA）治疗是否与婴幼儿癫痫患者维生素D缺乏有关，对25例服用VPA的癫痫患儿进行了一项横断面临床研究。每隔1至3个月测量血钙、磷、碱性磷酸酶、25-羟基维生素D[25(OH)D]的血药浓度以及血浆VPA水平。在初次和末次测量时，分别有8例（32%）和12例（42%）被认定为维生素D缺乏或不足。在女孩中，观察到血清25(OH)D水平呈下降趋势（<0.05）。联合治疗对女孩25(OH)D的纵向变化有显著负面影响（<0.05）。总之，我们的研究表明，VPA治疗后，高比例的女孩存在维生素D缺乏症。
