Gismondo M R, Lo Bue A M, Chisari G
Istituto di Microbiologia, Università di Catania.
G Batteriol Virol Immunol. 1987 Jan-Dec;80(1-12):15-24.
Bacterial antigens orally administered, have been showed by many Authors capable to stimulate immunity system, hinding thus the pathogen flora from gut-colonization. Founding on these findings, AA. of the present paper intend to point out by collected microbial data and M.E.S. photos, the activity of an oral polyvalent vaccine made by lysates strains of E.coli, enterococci, staphylococci and P.vulgaris, on normal intestinal flora of mice contemporaneously administered with a pathogenic strain of Salmonella enteritidis. Vaccine showed himself to be able enough to limit alterations of intestinal flora due to infection by the pathogens.
许多作者已表明，口服细菌抗原能够刺激免疫系统，从而阻止病原菌在肠道定植。基于这些发现，本文作者旨在通过收集的微生物数据和扫描电子显微镜照片，指出一种由大肠杆菌、肠球菌、葡萄球菌和普通变形杆菌裂解菌株制成的口服多价疫苗，对同时接种肠炎沙门氏菌致病菌株的小鼠正常肠道菌群的活性。疫苗显示出足以限制病原体感染引起的肠道菌群变化。
