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Do Alzheimer's Disease Risk Gene Products Actually Act in Microglia?

作者信息

Hashioka Sadayuki, Inoue Ken, Takeshita Haruo, Inagaki Masatoshi

机构信息

Department of Psychiatry, Faculty of Medicine, Shimane University, Izumo, Japan.

Research and Education Faculty, Medical Sciences Cluster, Health Service Center, Kochi University, Kochi, Japan.

出版信息

Front Aging Neurosci. 2020 Dec 3;12:589196. doi: 10.3389/fnagi.2020.589196. eCollection 2020.

DOI:10.3389/fnagi.2020.589196
PMID:33343331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7744292/
Abstract
摘要

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本文引用的文献

1
The Possible Causal Link of Periodontitis to Neuropsychiatric Disorders: More Than Psychosocial Mechanisms.牙周炎与神经精神障碍的可能因果关系：不仅仅是心理社会机制。
Int J Mol Sci. 2019 Jul 30;20(15):3723. doi: 10.3390/ijms20153723.
2
Single-cell transcriptomic analysis of Alzheimer's disease.阿尔茨海默病的单细胞转录组分析。
Nature. 2019 Jun;570(7761):332-337. doi: 10.1038/s41586-019-1195-2. Epub 2019 May 1.
3
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology.阿尔茨海默病患者脑脊液 sTREM2 的早期增加与 tau 相关的神经退行性变有关，但与淀粉样蛋白-β 病理学无关。
Mol Neurodegener. 2019 Jan 10;14(1):1. doi: 10.1186/s13024-018-0301-5.
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Microglia in Alzheimer's disease.阿尔茨海默病中的小胶质细胞。
J Cell Biol. 2018 Feb 5;217(2):459-472. doi: 10.1083/jcb.201709069. Epub 2017 Dec 1.
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TREM2 expression in the human brain: a marker of monocyte recruitment?TREM2 在人脑中的表达：单核细胞募集的标志物？
Brain Pathol. 2018 Sep;28(5):595-602. doi: 10.1111/bpa.12564. Epub 2017 Oct 30.
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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.TREM2-载脂蛋白E通路驱动神经退行性疾病中功能失调的小胶质细胞的转录表型。
Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008.
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The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.具有阿尔茨海默病保护作用的CD33剪接变体通过转移至细胞内池介导适应性功能丧失。
J Biol Chem. 2017 Sep 15;292(37):15312-15320. doi: 10.1074/jbc.M117.799346. Epub 2017 Jul 26.
8
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes.人类皮质小胶质细胞的转录组分析揭示了与年龄相关的变化。
Nat Neurosci. 2017 Aug;20(8):1162-1171. doi: 10.1038/nn.4597. Epub 2017 Jul 3.
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A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.一种与限制阿尔茨海默病发展相关的独特小胶质细胞类型。
Cell. 2017 Jun 15;169(7):1276-1290.e17. doi: 10.1016/j.cell.2017.05.018. Epub 2017 Jun 8.
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An environment-dependent transcriptional network specifies human microglia identity.一个依赖环境的转录网络决定了人类小胶质细胞的特性。
Science. 2017 Jun 23;356(6344). doi: 10.1126/science.aal3222. Epub 2017 May 25.