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钙/钙调蛋白复合物在植物应激状态下触发CAMTA转录机制：信号级联反应与分子调控

Ca/Calmodulin Complex Triggers CAMTA Transcriptional Machinery Under Stress in Plants: Signaling Cascade and Molecular Regulation.

作者信息

Iqbal Zahra, Shariq Iqbal Mohammed, Singh Surendra Pratap, Buaboocha Teerapong

机构信息

Molecular Crop Research Unit, Department of Biochemistry, Chulalongkorn University, Bangkok, Thailand.

Amity Institute of Biotechnology, Amity University, Uttar Pradesh, Lucknow Campus, Lucknow, India.

出版信息

Front Plant Sci. 2020 Dec 3;11:598327. doi: 10.3389/fpls.2020.598327. eCollection 2020.

DOI:10.3389/fpls.2020.598327
PMID:33343600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7744605/
Abstract

Calcium (Ca) ion is a critical ubiquitous intracellular second messenger, acting as a lead currency for several distinct signal transduction pathways. Transient perturbations in free cytosolic Ca ([Ca]) concentrations are indispensable for the translation of signals into adaptive biological responses. The transient increase in [Ca] levels is sensed by an array of Ca sensor relay proteins such as calmodulin (CaM), eventually leading to conformational changes and activation of CaM. CaM, in a Ca-dependent manner, regulates several transcription factors (TFs) that are implicated in various molecular, physiological, and biochemical functions in cells. CAMTA (calmodulin-binding transcription activator) is one such member of the Ca-loaded CaM-dependent family of TFs. The present review focuses on Ca as a second messenger, its interaction with CaM, and Ca/CaM-mediated CAMTA transcriptional regulation in plants. The review recapitulates the molecular and physiological functions of CAMTA in model plants and various crops, confirming its probable involvement in stress signaling pathways and overall plant development. Studying Ca/CaM-mediated CAMTA TF will help in answering key questions concerning signaling cascades and molecular regulation under stress conditions and plant growth, thus improving our knowledge for crop improvement.

摘要

钙离子（Ca）是一种至关重要的普遍存在的细胞内第二信使，作为多种不同信号转导途径的主要货币。游离胞质钙（[Ca]）浓度的瞬时扰动对于将信号转化为适应性生物学反应是必不可少的。[Ca]水平的瞬时升高由一系列钙传感器中继蛋白如钙调蛋白（CaM）感知，最终导致CaM的构象变化和激活。CaM以钙依赖的方式调节几种转录因子（TFs），这些转录因子参与细胞中的各种分子、生理和生化功能。钙调蛋白结合转录激活因子（CAMTA）是钙负载的CaM依赖型转录因子家族的一员。本综述重点关注作为第二信使的钙、其与CaM的相互作用以及植物中Ca/CaM介导的CAMTA转录调控。该综述概括了CAMTA在模式植物和各种作物中的分子和生理功能，证实了其可能参与胁迫信号通路和植物整体发育。研究Ca/CaM介导的CAMTA转录因子将有助于回答有关胁迫条件下和植物生长过程中的信号级联和分子调控的关键问题，从而增进我们对作物改良的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e5/7744605/1049d4c7ce04/fpls-11-598327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e5/7744605/1ab63120d19b/fpls-11-598327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e5/7744605/c439bae6808e/fpls-11-598327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e5/7744605/1049d4c7ce04/fpls-11-598327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e5/7744605/1ab63120d19b/fpls-11-598327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e5/7744605/c439bae6808e/fpls-11-598327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8e5/7744605/1049d4c7ce04/fpls-11-598327-g003.jpg

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