Choudhary Nilookumari, Sarode Gargi S, Yuwanati Monal, Maniyar Nikunj, Sarode Sachin C, Gadbail Amol R, Gondivkar Shailesh, Patil Shankargouda
Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaramnagar, Pimpri, Pune, 411018, Maharashtra, India.
Department of Oral Pathology & Microbiology, Peoples College of Dental Sciences, Bhopal, Madhya Pradesh, India.
J Oral Biol Craniofac Res. 2021 Jan-Mar;11(1):33-39. doi: 10.1016/j.jobcr.2020.11.012. Epub 2020 Nov 23.
Oral squamous cell carcinoma (OSCC) still lacks the valid prognosticator for survival. Tumor associated tissue eosinophilia (TATE) have been widely investigated in the literature but still there is no consensus viewpoint on its role as prognostic marker. With this view in mind, a systematic review and meta-analysis of studies that evaluated the overall risk of elevated TATE and survival in OSCC was conducted
A systematic literature search conducted to identify studies that have evaluated TATE in OSCC. Overall survival (OS), Disease Free Survival (DFS) Hazard ratio (HR) with 95% confidence interval) was extracted. HR was extrapolated if direct HR was not given in publication. Studies were pooled and combined hazard ratios (HRs) of High TATE for OS and DFS were calculated.
6 out of 874 articles were found eligible for systematic review and meta-analysis. High TATE was predictor of OS ( HR 0.45 (95% CI, 030-0.65, < 0.0001)) and DFS ( HR 2.33 (95% CI, 0.74-7.37)) in OSCC patients.
High TATE positively predicts OS and DFS in OSCC and thus can be regarded as an important survival prognosticator. Standardization of counting and reporting methodology for TATE count is recommended on future cohort studies.
口腔鳞状细胞癌（OSCC）仍然缺乏有效的生存预后指标。肿瘤相关组织嗜酸性粒细胞增多症（TATE）在文献中已得到广泛研究，但对于其作为预后标志物的作用仍没有共识性观点。基于这一观点，我们对评估OSCC中TATE升高的总体风险和生存情况的研究进行了系统评价和荟萃分析。
进行系统的文献检索，以识别评估OSCC中TATE的研究。提取总生存期（OS）、无病生存期（DFS）、风险比（HR）及95%置信区间。如果出版物中未给出直接的HR，则进行推断。对研究进行汇总，并计算高TATE组OS和DFS的合并风险比（HRs）。
874篇文章中有6篇符合系统评价和荟萃分析的条件。在OSCC患者中，高TATE是OS（HR 0.45（95%CI，0.30 - 0.65，P<0.0001））和DFS（HR 2.33（95%CI，0.74 - 7.37））的预测指标。
高TATE可积极预测OSCC的OS和DFS，因此可被视为重要的生存预后指标。建议在未来的队列研究中对TATE计数的计数和报告方法进行标准化。
