Wu Yi, Xu Jing, Liu Yiting, Zeng Yiyu, Wu Guojun
School of Stomatology, Central South University, Changsha, China.
Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China.
Front Oncol. 2020 Dec 4;10:592853. doi: 10.3389/fonc.2020.592853. eCollection 2020.
Coumarins are a class of compound with benzopyrone as their basic structure. Due to abundant sources, easy synthesis, and various pharmacological activities, coumarins have attracted extensive attention from researchers. In particular, coumarins have very significant anti-tumor abilities and a variety of anti-tumor mechanisms, including inhibition of carbonic anhydrase, targeting PI3K/Akt/mTOR signaling pathways, inducing cell apoptosis protein activation, inhibition of tumor multidrug resistance, inhibition of microtubule polymerization, regulating the reactive oxygen species, and inhibition of tumor angiogenesis, etc. This review focuses on the mechanisms and the research progress of coumarins against cancers in recent years.
香豆素是一类以苯并吡喃酮为基本结构的化合物。由于来源丰富、易于合成且具有多种药理活性，香豆素已引起研究人员的广泛关注。特别是，香豆素具有非常显著的抗肿瘤能力和多种抗肿瘤机制，包括抑制碳酸酐酶、靶向PI3K/Akt/mTOR信号通路、诱导细胞凋亡蛋白激活、抑制肿瘤多药耐药性、抑制微管聚合、调节活性氧以及抑制肿瘤血管生成等。本文综述了近年来香豆素抗癌症的机制及研究进展。
