Kumar Sandeep, Peterson Timothy R
Department of Internal Medicine, Division of Bone and Mineral Diseases, Department of Genetics, Institute for Public Health, Washington University School of Medicine, BJC Institute of Health, MO, USA.
Nutr Healthy Aging. 2020 Nov 3;5(4):239-246. doi: 10.3233/NHA-190064.
As the global population ages, there is increased interest in living longer and improving one's quality of life in later years. However, studying aging - the decline in body function - is expensive and time-consuming. And despite research success to make model organisms live longer, there still aren't really any feasible solutions for delaying aging in humans. With space travel, scientists and engineers couldn't know what it would take to get to the moon. They had to extrapolate from theory and shorter-range tests. Perhaps with aging, we need a similar moonshot philosophy. And though "shot" might imply medicine, perhaps we need to think beyond medical interventions. Like the moon once was, we seem a long way away from provable therapies to increase human healthspan (the healthy period of one's life) or lifespan (how long one lives). This review therefore focuses on radical proposals. We hope it might stimulate discussion on what we might consider doing significantly differently than ongoing aging research.
随着全球人口老龄化，人们对延长寿命以及提高晚年生活质量的兴趣日益浓厚。然而，研究衰老——身体机能的衰退——既昂贵又耗时。尽管在使模式生物寿命延长方面取得了研究成功，但对于延缓人类衰老，仍然没有真正可行的解决方案。在太空旅行方面，科学家和工程师们起初并不知道登上月球需要什么。他们不得不从理论和更短距离的测试中进行推断。或许对于衰老问题，我们也需要类似的大胆尝试理念。而且，尽管“尝试”可能意味着医学，但也许我们需要超越医学干预去思考。就像曾经的月球一样，我们似乎距离可证实的延长人类健康寿命（一个人生命中的健康时期）或寿命（一个人存活的时长）的疗法还很遥远。因此，本综述聚焦于激进的提议。我们希望它可能会激发关于我们可以考虑采取与当前衰老研究显著不同做法的讨论。
