Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
J Drug Target. 2021 Jul;29(6):563-575. doi: 10.1080/1061186X.2020.1867991. Epub 2021 Jan 5.
Antibacterial nanofibers have a great potential for effective treatment of infections. They act as drug reservoir systems that release higher quantities of antibacterial agents/drug in a controlled manner at infection sites and prevent drug resistance, while concomitantly decreasing the systemic toxicity. With this drug delivery system, it is also possible to achieve multiple drug entrapment and also simultaneous or sequential release kinetics at the site of action. Therefore, advances in antibacterial nanofibers as drug delivery systems were overviewed within this article. Recently published data on antibacterial drug delivery was also summarised to provide a view of the current state of art in this field. Although antibacterial use seems to be limited and one can ask that ''; recent update literatures in this field highlighted the use of nanofibers from very different perspectives. We believe that readers will be benefiting this review for enlightening of novel ideas.
抗菌纳米纤维在有效治疗感染方面具有巨大的潜力。它们作为药物储库系统，在感染部位以可控的方式释放更高数量的抗菌剂/药物，防止耐药性的产生，同时降低全身毒性。通过这种药物输送系统，还可以实现多种药物包封，并在作用部位实现同时或顺序的释放动力学。因此，本文综述了抗菌纳米纤维作为药物输送系统的进展。最近关于抗菌药物输送的出版数据也进行了总结，以提供该领域的最新技术状况。尽管抗菌药物的使用似乎受到限制，人们可能会问“；该领域的最新文献强调了从非常不同的角度使用纳米纤维。我们相信，读者将从这篇综述中受益，获得新的思路。
