Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa.
Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, South Africa; Department of Pharmaceutics and Pharmacy Practice, School of Pharmacy and Health Sciences, United States International University-Africa, P. O. Box 14634-00800, Nairobi, Kenya.
J Control Release. 2024 Jul;371:237-257. doi: 10.1016/j.jconrel.2024.05.047. Epub 2024 May 31.
Nanodrug delivery systems (NDDS) continue to be explored as novel strategies enhance therapy outcomes and combat microbial resistance. The need for the formulation of smart drug delivery systems for targeting infection sites calls for the engineering of responsive chemical designs such as dynamic covalent bonds (DCBs). Stimuli response due to DCBs incorporated into nanosystems are emerging as an alternative way to target infection sites, thus enhancing the delivery of antibacterial agents. This leads to the eradication of bacterial infections and the reduction of antimicrobial resistance. Incorporating DCBs on the backbone of the nanoparticles endows the systems with several properties, including self-healing, controlled disassembly, and stimuli responsiveness, which are beneficial in the delivery and release of the antimicrobial at the infection site. This review provides a comprehensive and current overview of conventional DCBs-based nanosystems, stimuli-responsive DCBs-based nanosystems, and targeted DCBs-based nanosystems that have been reported in the literature for antibacterial delivery. The review emphasizes the DCBs used in their design, the nanomaterials constructed, the drug release-triggering stimuli, and the antibacterial efficacy of the reported DCBs-based nanosystems. Additionally, the review underlines future strategies that can be used to improve the potential of DCBs-based nanosystems to treat bacterial infections and overcome antibacterial resistance.
纳米药物递送系统（NDDS）作为一种新策略，不断被探索以提高治疗效果和对抗微生物耐药性。需要针对感染部位的智能药物递送系统的制剂，这就需要工程化响应性化学设计，例如动态共价键（DCB）。由于纳米系统中包含 DCB 而产生的刺激响应，正在成为靶向感染部位的一种替代方法，从而增强了抗菌剂的递送。这导致了细菌感染的消除和抗菌药物耐药性的降低。将 DCB 结合到纳米颗粒的主链上，赋予了系统多种特性，包括自修复、可控拆卸和刺激响应性，这在感染部位的抗菌剂输送和释放方面是有益的。本综述提供了文献中报道的用于抗菌药物递送的基于常规 DCB 的纳米系统、基于刺激响应性 DCB 的纳米系统和基于靶向 DCB 的纳米系统的全面和最新概述。本综述强调了设计中使用的 DCB、构建的纳米材料、药物释放触发刺激以及报道的基于 DCB 的纳米系统的抗菌功效。此外，本综述强调了未来可以用于提高基于 DCB 的纳米系统治疗细菌感染和克服抗菌耐药性的潜力的策略。
