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基于钼的杂化纳米复合材料在癌症治疗、诊断和生物传感应用中的研究进展:当前进展和未来突破

Molybdenum-based hetero-nanocomposites for cancer therapy, diagnosis and biosensing application: Current advancement and future breakthroughs.

机构信息

Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India.

Faculty of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India.

出版信息

J Control Release. 2021 Feb 10;330:257-283. doi: 10.1016/j.jconrel.2020.12.015. Epub 2020 Dec 18.

Abstract

In recent years, there have been significant advancements in the nanotechnology for cancer therapy. Even though molybdenum disulphide (MoS2)-based nanocomposites demonstrated extensive applications in biosensing, bioimaging, phototherapy, the review article focusing on MoS2 nanocomposite platform has not been accounted for yet. The review summarizes recent strategies on design and fabrication of MoS2-based nanocomposites and their modulated properties in cancer treatment. The review also discussed several therapeutic strategies (photothermal, photodynamic, immunotherapy, gene therapy and chemotherapy) and their combinations for efficient cancer therapy along with certain case studies. The review also inculcates various diagnostic techniques viz. magnetic resonance imaging, computed tomography, photoacoustic imaging and fluorescence imaging for diagnosis of cancer.

摘要

近年来,癌症治疗的纳米技术取得了重大进展。尽管基于二硫化钼(MoS2)的纳米复合材料在生物传感、生物成像、光疗等方面得到了广泛的应用,但尚未有关于 MoS2 纳米复合材料平台的综述文章。本文综述了 MoS2 基纳米复合材料的设计和制备策略及其在癌症治疗中的调控性能。还讨论了几种治疗策略(光热、光动力、免疫治疗、基因治疗和化学治疗)及其组合在癌症治疗中的应用,以及一些案例研究。还介绍了各种诊断技术,如磁共振成像、计算机断层扫描、光声成像和荧光成像,用于癌症诊断。

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