School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, China.
Eur J Pharmacol. 2021 Feb 5;892:173796. doi: 10.1016/j.ejphar.2020.173796. Epub 2020 Dec 17.
Fruit of Schisandra chinensis Turcz. (Baill.) (S. chinensis) is a traditional herbal medicine widely used in China, Korea, and many other east Asian countries. At present, S. chinensis commonly forms Chinese medicinal formulae with other herbal medicines to treat liver disease and neurological disease in clinical. Modern researches indicated that lignans were the main active ingredients of S. chinensis with high content and novel dibenzocyclooctadiene skeletal structure, exhibited considerable antioxidant, anti-inflammatory, and neuroprotective properties. Additionally, some of these lignans also showed certain potentials in anti-cancer, anti-fibrosis, and other effects. In the current review, we summarize literature reported lignans from S. chinensis in the past five years, and highlight the molecular mechanisms of lignans in exerting their biological functions. Also, we point out some deficiencies of existing researches and discuss the future direction of lignans study.
五味子（Schisandra chinensis Turcz. (Baill.)）的果实是一种传统的草药，在中国、韩国和许多其他东亚国家广泛使用。目前，五味子通常与其他草药一起组成中药方剂，用于治疗临床中的肝病和神经疾病。现代研究表明，木脂素是五味子的主要活性成分，具有含量高、新颖的二苯并环辛二烯骨架结构，表现出相当强的抗氧化、抗炎和神经保护特性。此外，其中一些木脂素在抗癌、抗纤维化等方面也显示出一定的潜力。在本综述中，我们总结了过去五年中有关五味子木脂素的文献，并强调了木脂素发挥其生物学功能的分子机制。同时，我们指出了现有研究的一些不足，并讨论了木脂素研究的未来方向。
