Yang Yu-Tong, Zhang Yuan, Bian Yu, Zhu Juan, Feng Xue-Song
School of Pharmacy, China Medical University, Shenyang, 110122, China.
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Food Chem X. 2025 Feb 3;26:102249. doi: 10.1016/j.fochx.2025.102249. eCollection 2025 Feb.
Lignans are widely used as dietary supplements within health foods. However, excess addition of lignans can induce adverse reactions, therefore, it is necessary to develop rapid, effective, economical, and environmentally friendly extraction and purification methods to enhance lignan extraction efficiency. Recently, the advancement of sample pretreatment has been primarily directed towards the application of novel extraction solvents (e.g., supramolecular solvents) in dispersive liquid-liquid microextraction, the miniaturization of solid-phase extraction, the utilization of innovative adsorbent materials in dispersive solid-phase microextraction and matrix-assisted solid-phase extraction, and the employment of subcritical water extraction technology. Up to now, no systematic review has encompassed these advancements. Consequently, this review provides a comprehensive overview of the extraction and purification methods of lignans from plant-derived foods since 2017, with a particular focus on the application of microextraction technologies and new materials. It also analyzes the advantages and disadvantages of these methods and discusses their future developing trends.
木脂素在保健食品中被广泛用作膳食补充剂。然而，过量添加木脂素会引发不良反应，因此，有必要开发快速、有效、经济且环保的提取和纯化方法，以提高木脂素的提取效率。近年来，样品预处理的进展主要集中在以下方面：在分散液液微萃取中应用新型萃取溶剂（如超分子溶剂）、固相萃取的小型化、在分散固相微萃取和基质辅助固相萃取中使用创新吸附材料以及采用亚临界水萃取技术。到目前为止，尚无系统综述涵盖这些进展。因此，本综述全面概述了自2017年以来从植物源性食品中提取和纯化木脂素的方法，特别关注微萃取技术和新材料的应用。同时分析了这些方法的优缺点，并探讨了它们未来的发展趋势。
