Nuclear Medicine Department, Shohada Tajrish Hospital, School of Medicine.
Department of Urology, Shahid Modarress Hospital, Shahid Beheshti University of Medical Sciences.
Nucl Med Commun. 2021 May 1;42(5):469-475. doi: 10.1097/MNM.0000000000001359.
Renal transplantation is the gold standard treatment for chronic kidney disease. Renal scintigraphy has been performed widely to evaluate postsurgical complications of transplantation, but there are little data regarding 99mTc-EC scintigraphy in kidney transplantation.
This was a prospective descriptive study. All patients who underwent kidney transplantation and passed an uneventful postoperative period entered the study. Demographic characteristics, including age, gender, biochemical parameters before and after the transplantation and 99mTc-EC parameters including time to max, time to ½ max, slope from max to ½ max, upslope time interval and time to 2/3 max as well as episodes of rejection, were recorded. Patients were then followed up for 1 year at 3-, 6-, 9- and 12-month intervals.
Forty-one patients who underwent renal transplantation entered the study. Mean ± SD age of patients was 40.65 ± 12.84 years (min 17 and max 74 years). In total, 25% (10) of patients experienced one or two episodes of rejection and were hospitalized. Time of max, time of 1/2 max, time from max to 1/2 max, time of 2/3 max, time from max to 2/3 max and upslope time interval had a significant association with transplant rejection using a Cox regression model. With 1-min increase in time of max, the risk of rejection increased by 27% (hazard ratio = 1.27; CI, 1.03--1.56) and with 1-min increase in time of 1/2 max, the risk of rejection increased by 28% (hazard ratio = 1.28; CI, 1.14-1.45).
99mTc-EC renal scintigrahpy was able to predict kidney transplantation rejection in our patients. 99mTc-EC renal scintigrahpy is beneficial to evaluate transplant kidney function to prevent complications and helps close follow-up.
肾移植是治疗慢性肾病的金标准。肾闪烁显像术已广泛用于评估移植后的术后并发症，但关于 99mTc-EC 闪烁显像术在肾移植中的数据很少。
这是一项前瞻性描述性研究。所有接受肾移植并度过平稳术后期的患者均进入研究。记录人口统计学特征，包括年龄、性别、移植前后的生化参数以及 99mTc-EC 参数，包括达峰时间、半峰时间、达峰到半峰斜率、上升斜率时间间隔和达峰到 2/3 时间以及排斥反应发作次数。然后，患者在 3、6、9 和 12 个月的间隔时间进行 1 年的随访。
41 例接受肾移植的患者进入研究。患者的平均年龄为 40.65±12.84 岁（最小 17 岁，最大 74 岁）。共有 25%（10 例）的患者经历了一次或两次排斥反应发作并住院治疗。使用 Cox 回归模型，达峰时间、半峰时间、达峰到半峰时间、达峰到 2/3 时间、达峰到 2/3 时间和上升斜率时间间隔与移植排斥反应有显著相关性。达峰时间增加 1 分钟，排斥反应的风险增加 27%（危险比=1.27；CI，1.03-1.56），半峰时间增加 1 分钟，排斥反应的风险增加 28%（危险比=1.28；CI，1.14-1.45）。
99mTc-EC 肾闪烁显像术能够预测我们患者的肾移植排斥反应。99mTc-EC 肾闪烁显像术有助于评估移植肾功能，预防并发症，并有助于密切随访。
