Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
IrsiCaixa - AIDS Research Institute, Health Research Institute Germans Trias I Pujol Research Institute, IGTP, Badalona, Spain.
J Food Biochem. 2021 Jan;45(1):e13590. doi: 10.1111/jfbc.13590. Epub 2020 Dec 21.
Diabetes is a metabolic disorder whose complications are among the leading cause of death. In this study, the antidiabetic effect of L-alanine was tested in alloxan-induced diabetic rats. Thirty-five male albino Wistar rats were divided into five groups viz; Group I and II: nondiabetic and diabetic controls respectively; Group III and IV: 150 and 300 mg/kg b.w. L-alanine treated, respectively; Group V: glibenclamide (0.5 mg/kg b.w.) treated. Weight and blood glucose were monitored during the study, while liver and kidney functions, lipid profile, and antioxidant markers were examined at the end of the study. The outcomes indicate that 300 mg/kg L-alanine resulted to a significant decrease (p < .05) in weight and blood glucose. L-alanine restored tissue antioxidants, kidney, and liver functions by improving important parameters. Histopathological studies showed the potential of L-alanine in regeneration of the islets of Langerhans. These findings suggest that L-alanine has an alleviating effect on alloxan-induced diabetes. PRACTICAL APPLICATIONS: Several medicinal plants have been tested for their antidiabetic potentials, however, the isolation of the active compounds from these plants for medicinal use is often challenging. Here, we present data that suggests the potential use of a pure and harmless amino acid compound (L-alanine) for the management of diabetes. L-alanine is readily available, cheap and can also be found in many foods we eat. Therefore, L-alanine may be taken by diabetic patients as a food supplement for the treatment/management of diabetes or taken as part of foods rich in the amino acid such as meat, poultry, fish, eggs, and dairy products.
糖尿病是一种代谢紊乱，其并发症是导致死亡的主要原因之一。在这项研究中，研究人员测试了 L-丙氨酸对四氧嘧啶诱导的糖尿病大鼠的降血糖作用。35 只雄性白化 Wistar 大鼠被分为五组：第 I 组和第 II 组分别为非糖尿病和糖尿病对照组；第 III 组和第 IV 组分别给予 150 和 300mg/kg b.w. L-丙氨酸治疗；第 V 组给予格列本脲（0.5mg/kg b.w.）治疗。在研究过程中监测体重和血糖，研究结束时检查肝功能、肾功能、血脂谱和抗氧化标志物。结果表明，300mg/kg L-丙氨酸可显著降低（p<.05）体重和血糖。L-丙氨酸通过改善重要参数来恢复组织抗氧化剂、肾脏和肝功能。组织病理学研究表明 L-丙氨酸具有胰岛再生的潜力。这些发现表明 L-丙氨酸对四氧嘧啶诱导的糖尿病具有缓解作用。实际应用：已经测试了几种药用植物的降血糖潜力，但是，从这些植物中分离出活性化合物用于药用常常具有挑战性。在这里，我们提供的数据表明，一种纯的、无害的氨基酸化合物（L-丙氨酸）可能具有用于治疗糖尿病的潜力。L-丙氨酸易于获得，价格低廉，而且可以在我们吃的许多食物中找到。因此，糖尿病患者可以将 L-丙氨酸作为治疗/管理糖尿病的饮食补充剂，或者作为富含该氨基酸的食物的一部分食用，如肉类、家禽、鱼类、鸡蛋和奶制品。
