Student Research Committee, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Maraghe University of Medical Sciences, Department of Nutrition and Food Sciences, Department of Nutrition and Food Sciences, Iran.
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Diabetes Res Clin Pract. 2021 Feb;172:108634. doi: 10.1016/j.diabres.2020.108634. Epub 2020 Dec 23.
The aim of the present study was to investigate whether circulating levels of spexin is related to metabolic syndrome, some dietary intakes (Total energyintake, Macronutrient intakes) and body composition in children.
90 children were recruited in the present cross sectional study. Anthropometric measures, body composition, blood pressure, dietary intakes, resting metabolic rate, physical activity level, appetite status, pubertal stage, serum spexin, fasting blood glucose, high-sensitivity C-reactive protein, insulin and lipid profile were measured using standard techniques.
14 children met the criteria for metabolic syndrome. Median (IQR) of spexin levels were significantly lower in children with high fat mass and children with higher systolic blood pressure (SBP), compared to children with normal fat mass and normal SBP: (P < 0.05). A protective independent effect was detected for the highest tertile of serum spexin on metabolic syndrome in adjusted models; Crude OR (CI): 0.23 (0.04-1.2), P-trend = 0.08; Model 1: OR (CI): 0.15(0.02-1.01), P-trend = 0.05; Model 2: OR (CI): 0.10 (0.01-0.90), P-trend = 0.03. There was a significant negative association between spexin and total dietary fat intake (r= - 0.21; P < 0.04).
This findings can further highlight the importance of the relationship between spexin, adipose tissue and adipose tissue metabolism.
本研究旨在探讨循环分泌素水平与儿童代谢综合征、某些饮食摄入（总能量摄入、宏量营养素摄入）和身体成分的关系。
本横断面研究纳入了 90 名儿童。采用标准技术测量了人体测量学指标、身体成分、血压、饮食摄入、静息代谢率、体力活动水平、食欲状况、青春期阶段、血清分泌素、空腹血糖、高敏 C 反应蛋白、胰岛素和血脂谱。
14 名儿童符合代谢综合征标准。与正常体脂和正常收缩压（SBP）的儿童相比，体脂较高和 SBP 较高的儿童的分泌素水平中位数（IQR）显著较低（P<0.05）。在调整模型中，血清分泌素最高三分位对代谢综合征有独立的保护作用；粗 OR（CI）：0.23（0.04-1.2），P 趋势=0.08；模型 1：OR（CI）：0.15（0.02-1.01），P 趋势=0.05；模型 2：OR（CI）：0.10（0.01-0.90），P 趋势=0.03。分泌素与总膳食脂肪摄入呈显著负相关（r=-0.21；P<0.04）。
这些发现可以进一步强调分泌素、脂肪组织和脂肪组织代谢之间关系的重要性。
