Vocational Higher School of Healthcare Studies, Health Services Vocational School, Batman University, Batman, Turkey.
Department of Histology and Embryology, Faculty of Veterinary Medicine, Selçuk University, Konya, Turkey.
Biol Trace Elem Res. 2023 Apr;201(4):1806-1815. doi: 10.1007/s12011-022-03276-6. Epub 2022 May 12.
Aluminum (AL) is an important nephrotoxic agent with a high daily exposure rate and property of accumulation in tissues. This study aimed to investigate the potential protective efficacy of N-acetylcysteine (NAC) against AL exposure-induced nephrotoxicity in rats. Twenty-eight rats were randomly divided into 4 groups as control, N-acetylcysteine group (NC), AL, and AL + NC, with an equal number of rats in each group (n = 7). No application was made to the control group. A total of 150 mg/kg/day NAC was administered to the NC group and 30 mg/kg/day AL was administered to the AL group intraperitoneally (i.p.). The AL + NC group received 30 mg/kg/day AL and 150 mg/kg/day NAC i.p. Biochemical parameters in blood serum and histopathological changes in kidney tissue, oxidative stress parameters, spexin (SPX), and apoptotic protein levels were examined after 15 days. Histopathological changes, biochemical parameters, oxidative stress parameters, and apoptotic protein levels were significantly irregular in the AL group compared to the control group. Moreover, SPX levels increased in the AL group. However, NAC treatment regulated AL exposure-related changes in the AL + NC group. NAC treatment may have a prophylactic effect against nephrotoxicity due to AL exposure. SPX may play a role in AL-induced nephrotoxicity.
铝（AL）是一种重要的肾毒性物质，具有很高的日暴露率和在组织中积累的特性。本研究旨在探讨 N-乙酰半胱氨酸（NAC）对大鼠 AL 暴露诱导的肾毒性的潜在保护作用。28 只大鼠随机分为 4 组，即对照组、N-乙酰半胱氨酸组（NC）、AL 组和 AL+NC 组，每组各有 7 只大鼠。对照组不进行任何处理。NC 组给予 150mg/kg/天的 NAC，AL 组给予 30mg/kg/天的 AL，均腹腔内给药。AL+NC 组给予 30mg/kg/天的 AL 和 150mg/kg/天的 NAC 腹腔内给药。在 15 天后检测血清生化参数和肾组织的组织病理学变化、氧化应激参数、分泌素（SPX）和凋亡蛋白水平。与对照组相比，AL 组的组织病理学变化、生化参数、氧化应激参数和凋亡蛋白水平明显异常。此外，AL 组的 SPX 水平升高。然而，在 AL+NC 组中，NAC 处理调节了与 AL 暴露相关的变化。NAC 治疗可能对 AL 暴露引起的肾毒性具有预防作用。SPX 可能在 AL 诱导的肾毒性中发挥作用。
