鸭源多重耐药不动杆菌中 Tet(X5)和 NDM-3 的共存与特征。
Coexistence and characterization of Tet(X5) and NDM-3 in the MDR-Acinetobacter indicus of duck origin.
机构信息
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products & Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, 310021, China; Department of Pathogen Biology & Microbiology and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products & Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, 310021, China.
出版信息
Microb Pathog. 2021 Jan;150:104697. doi: 10.1016/j.micpath.2020.104697. Epub 2020 Dec 24.
Tigecycline and carbapenem are last-resort antibiotics for serious infections caused by pathogens with multi-drug resistance (MDR). Whereas, bacterial pathogens with co-resistance to tigecycline and carbapenem are poorly addressed. Here we report a tigecycline- and carbapenem-resistant Acinetobacter indicus strain HY20 of duck origin, which co-produces Tet(X5) and NDM-3. Tet(X5) is harbored by a novel plasmid pAI01 (116,992 bp long), which carries 10 antimicrobial resistance genes (AMRs), and heavy metal resistance system cobalt-zinc-cadmium (czc) gene cluster. Unlike that tet(X5) is located in the res-tet(X5)-xerD segment of plasmid, the chromosomal bla is flanked by insertion ISAba125. Collectively, our result represents an example of co-carriage of tet(X5) and bla, heightening the importance of AMR surveillance needed in poultry production.
替加环素和碳青霉烯类抗生素是治疗多重耐药（MDR）病原体引起的严重感染的最后手段。然而，对于同时对替加环素和碳青霉烯类抗生素具有耐药性的细菌病原体，目前的治疗方法还很有限。在这里，我们报告了一株来源于鸭子的替加环素和碳青霉烯类抗生素耐药的鲍曼不动杆菌 HY20 菌株，该菌株同时产生 Tet(X5)和 NDM-3。Tet(X5)位于一个新型质粒 pAI01（长 116992bp）上，该质粒携带 10 个抗生素耐药基因（AMRs）和重金属耐药系统钴-锌-镉（czc）基因簇。与质粒中的 res-tet(X5)-xerD 片段中存在 tet(X5)不同，染色体上的 bla 被插入序列 ISAba125 所包围。总的来说，我们的研究结果代表了 tet(X5)和 bla 同时携带的一个例子，这凸显了在禽类养殖中进行抗生素耐药性监测的重要性。
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