State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products & Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Hainan Institute of Zhejiang University, Sanya 572025, China.
Cells. 2022 Nov 3;11(21):3480. doi: 10.3390/cells11213480.
Antimicrobial-resistant (AMR) pathogens are a significant threat to public health worldwide. However, the primary carrier of AMR genes, particularly against last-resort antibiotics, is still only partially studied in Chinese hospitals. In a sentinel hospital in China, we collected 157 strains from patients between January and July 2021. One -, nine -, and one -positive recovered from inpatients were identified as resistant to meropenem and colistin. There are 37 virulence genes discovered in the 11 strains, including in strain EC21Z-147 (O128: H4), which belongs to the enteroaggregative (EAEC). The gene is distributed into distinct ST types, including ST48, ST616, ST410, ST711, and ST2003, while the gene was identified in ST117. The conjugative plasmids IncX3, IncI1-I, and IncI2 mediated the and genes detected among inpatients. Notably, the youngest age at which -positive has been reported was at one day old, in a child in which the strain is closely related to strains with animal origins. Hospitals are major environments for the spread and dissemination of critical virulence and AMR genes, which requires active monitoring systems at the genome level to surveil the spread of virulence and AMR.
抗微生物药物耐药性（AMR）病原体是全球公共卫生的重大威胁。然而，在中国医院中，针对最后手段抗生素的 AMR 基因的主要载体仍仅部分研究。在中国的一家哨点医院，我们从 2021 年 1 月至 7 月的住院患者中收集了 157 株菌株。从住院患者中分离出一株对美罗培南和黏菌素耐药的一株，一株对美罗培南耐药的一株，一株对黏菌素耐药的一株。在 11 株菌中发现了 37 种毒力基因，包括一株 EC21Z-147 株（O128：H4）中的，该菌属于肠聚集性大肠杆菌（EAEC）。基因分布在不同的 ST 型中，包括 ST48、ST616、ST410、ST711 和 ST2003，而基因则在 ST117 中被鉴定。IncX3、IncI1-I 和 IncI2 可携带接合质粒介导的和基因在住院患者中检测到。值得注意的是，报道的年龄最小的阳性是在一天大的婴儿中，该菌株与具有动物来源的菌株密切相关。医院是传播和扩散关键毒力和 AMR 基因的主要环境，需要在基因组水平上建立主动监测系统，以监测毒力和 AMR 的传播。
