University of São Paulo - Department of Surgery - Brazil.
University of São Paulo - Department of Surgery - Brazil.
Top Companion Anim Med. 2021 Mar;42:100506. doi: 10.1016/j.tcam.2020.100506. Epub 2020 Dec 23.
Strong to moderate vascular endothelial growth factor (VEGF) expression may be a negative prognostic factor in canine mast cell tumors (MCTs). This study set out to determine the prognostic value of combined analysis of VEGF-A immunoreactivity, clinical presentation, patient staging, and tumor histologic grade in canine MCTs. In this study, intense VEGF staining was significantly associated with decreased survival (P = .025). Immunohistochemical expression of VEGF is not routinely employed as a prognostic factor in canine MCT workup. However, results of this study support the inclusion of this marker in the MCT prognostic panel. Investigation of VEGF expression may assist in the development of anti-VEGF drugs.
强烈至中度的血管内皮生长因子（VEGF）表达可能是犬肥大细胞瘤（MCT）的一个预后不良因素。本研究旨在确定 VEGF-A 免疫组化反应、临床表现、患者分期和肿瘤组织学分级联合分析在犬 MCT 中的预后价值。在本研究中，VEGF 染色强度与生存时间缩短显著相关（P=0.025）。VEGF 的免疫组化表达在犬 MCT 检查中通常不作为预后因素。然而，本研究的结果支持将该标志物纳入 MCT 预后指标。对 VEGF 表达的研究可能有助于开发抗 VEGF 药物。
