Laboratory of Medicinal and Computational Chemistry (LQMC), Centre for Research and Innovation in Biodiversity and Drug Discovery (CIBFar), Institute of Physics of São Carlos, University of São Paulo (USP), São Carlos, Brazil.
Nuclei of Bioassays, Biosynthesis and Ecophysiology of Natural Products (NuBBE), Department of Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, Brazil.
Planta Med. 2021 Feb;87(1-02):6-23. doi: 10.1055/a-1320-4610. Epub 2020 Dec 21.
Natural products are a valuable source of biologically active compounds and continue to play an important role in modern drug discovery due to their great structural diversity and unique biological properties. Brazilian biodiversity is one of the most extensive in the world and could be an effective source of new chemical entities for drug discovery. Mosquitoes are vectors for the transmission of dengue, Zika, chikungunya, yellow fever, and many other diseases of public health importance. These diseases have a major impact on tropical and subtropical countries, and their incidence has increased dramatically in recent decades, reaching billions of people at risk worldwide. The prevention of these diseases is mainly through vector control, which is becoming more difficult because of the emergence of resistant mosquito populations to the chemical insecticides. Strategies to provide efficient and safe vector control are needed, and secondary metabolites from plant species from the Brazilian biodiversity, especially Cerrado, that are biologically active for mosquito control are herein highlighted. Also, this is a literature revision of targets as insights to promote advances in the task of developing active compounds for vector control. In view of the expansion and occurrence of arboviruses diseases worldwide, scientific reviews on bioactive natural products are important to provide molecular models for vector control and contribute with effective measures to reduce their incidence.
天然产物是具有生物活性的化合物的宝贵来源，由于其结构多样性和独特的生物特性，它们在现代药物发现中继续发挥着重要作用。巴西的生物多样性是世界上最广泛的之一，它可能是发现新药的新化学实体的有效来源。蚊子是传播登革热、寨卡、基孔肯雅热、黄热病和许多其他重要公共卫生疾病的媒介。这些疾病对热带和亚热带国家有重大影响，近几十年来，它们的发病率急剧上升，全世界有数十亿人面临风险。这些疾病的预防主要通过病媒控制来实现，但由于化学杀虫剂对蚊子种群的抗药性的出现，病媒控制变得更加困难。需要提供有效和安全的病媒控制策略，本文重点介绍了巴西生物多样性（尤其是塞拉多）植物物种的次生代谢产物，这些产物对控制蚊子具有生物活性。此外，这也是对目标的文献综述，为推动开发用于病媒控制的活性化合物的任务提供了新的见解。鉴于全世界虫媒病毒疾病的扩大和发生，关于生物活性天然产物的科学综述对于提供病媒控制的分子模型以及提供有效措施减少其发病率非常重要。
