单克隆抗体对神经节苷脂内酯的不同反应性。

Different reactivities of monoclonal antibodies to ganglioside lactones.

作者信息

Tai T, Kawashima I, Tada N, Ikegami S

机构信息

Tokyo Metropolitan Institute of Medical Science, Japan.

出版信息

Biochim Biophys Acta. 1988 Jan 19;958(1):134-8. doi: 10.1016/0005-2760(88)90255-x.

DOI:10.1016/0005-2760(88)90255-x

PMID:3334863

Abstract

Six murine monoclonal antibodies were found to react with ganglioside GD2 lactone as well as purified ganglioside GD2. However, the reactivities of these antibodies to various ganglioside lactones were found to differ from each other. Four antibodies only reacted with GD2 lactones, while the other two cross-reacted with lactones of other gangliosides such as GD1b and GT1b.

摘要

发现六种鼠单克隆抗体可与神经节苷脂GD2内酯以及纯化的神经节苷脂GD2发生反应。然而，发现这些抗体对各种神经节苷脂内酯的反应性彼此不同。四种抗体仅与GD2内酯反应，而另外两种则与其他神经节苷脂如GD1b和GT1b的内酯发生交叉反应。