一种与人脑神经节苷脂GD1b特异性反应的单克隆抗体。
A monoclonal antibody reacting specifically with ganglioside GD1b in human brain.
作者信息
Fredman P, Jeansson S, Lycke E, Svennerholm L
出版信息
FEBS Lett. 1985 Sep 9;189(1):23-6. doi: 10.1016/0014-5793(85)80834-6.
PMID:4029397
Abstract
A mouse monoclonal antibody directed against one of the major human brain gangliosides, GD1b, has been produced. The antibody binds specifically to the carbohydrate structure of GD1b as it does not react with structurally related gangliosides like GM1, GD2, GT1b or Fuc-GM1, or any other ganglioside of human brain. The results further indicate that terminal galactose as well as the disialosyl group linked to the inner galactose moiety are involved in binding to the antibody.
摘要
已制备出一种针对人类主要脑苷脂之一GD1b的小鼠单克隆抗体。该抗体特异性结合GD1b的碳水化合物结构，因为它不与结构相关的神经节苷脂如GM1、GD2、GT1b或Fuc-GM1，或人脑的任何其他神经节苷脂发生反应。结果进一步表明，末端半乳糖以及与内部半乳糖部分相连的二唾液酸基团参与了与抗体的结合。
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