Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.
Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Biomolecules. 2020 Dec 17;10(12):1688. doi: 10.3390/biom10121688.
The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response. Thus, a role in inflammatory diseases associated with the generation of large amounts of reactive oxygen species (ROS) seems obvious. In line with this, data obtained in cell culture experiments and preclinical settings have shown that Nrf2 is important in regulating target genes that are necessary to ensure cellular redox balance. Additionally, Nrf2 is involved in the induction of phase II drug metabolizing enzymes, which are important both in degrading and converting drugs into active forms, and into putative carcinogens. Therefore, Nrf2 has also been implicated in tumorigenesis. This must be kept in mind when new therapy approaches are planned for the treatment of sepsis. Therefore, this review highlights the function of Nrf2 in sepsis with a special focus on the translation of rodent-based results into sepsis patients in the intensive care unit (ICU).
转录因子 NF-E2 p45 相关因子 2（Nrf2）是抗氧化和解毒细胞反应的既定主调节因子。因此，它在与大量活性氧（ROS）生成相关的炎症性疾病中发挥作用似乎是显而易见的。与此一致的是，细胞培养实验和临床前研究获得的数据表明，Nrf2 对于调节确保细胞氧化还原平衡所必需的靶基因很重要。此外，Nrf2 参与诱导 II 相药物代谢酶，这些酶在降解和将药物转化为活性形式以及潜在致癌物质方面都很重要。因此，Nrf2 也与肿瘤发生有关。在为脓毒症治疗计划新的治疗方法时，必须牢记这一点。因此，本综述重点介绍了 Nrf2 在脓毒症中的功能，特别关注将基于啮齿动物的结果转化为重症监护病房（ICU）中脓毒症患者的情况。
