Department of Applied Health Science, Indiana University, Bloomington, IN, USA.
Department of Psychology, Arizona State University, Tempe, Arizona, USA.
Dev Psychopathol. 2022 Feb;34(1):171-182. doi: 10.1017/S0954579420001066. Epub 2020 Dec 22.
Aggressive behavior in middle childhood can contribute to peer rejection, subsequently increasing risk for substance use in adolescence. However, the quality of peer relationships a child experiences can be associated with his or her genetic predisposition, a genotype-environment correlation (rGE). In addition, recent evidence indicates that psychosocial preventive interventions can buffer genetic predispositions for negative behavior. The current study examined associations between polygenic risk for aggression, aggressive behavior, and peer rejection from 8.5 to 10.5 years, and the subsequent influence of peer rejection on marijuana use in adolescence (n = 515; 256 control, 259 intervention). Associations were examined separately in control and intervention groups for children of families who participated in a randomized controlled trial of the family-based preventive intervention, the Family Check-Up . Using time-varying effect modeling (TVEM), polygenic risk for aggression was associated with peer rejection from approximately age 8.50 to 9.50 in the control group but no associations were present in the intervention group. Subsequent analyses showed peer rejection mediated the association between polygenic risk for aggression and adolescent marijuana use in the control group. The role of rGEs in middle childhood peer processes and implications for preventive intervention programs for adolescent substance use are discussed.
儿童中期的攻击行为可能导致同伴排斥，进而增加青少年时期物质使用的风险。然而，孩子经历的同伴关系的质量可能与其遗传倾向有关，即基因型-环境相关(rGE)。此外，最近的证据表明，心理社会预防干预可以缓冲负面行为的遗传倾向。本研究从 8.5 岁到 10.5 岁，考察了攻击性多基因风险、攻击行为与同伴排斥之间的关系，以及同伴排斥对青少年大麻使用的后续影响(共 515 名参与者，其中 256 名对照组，259 名干预组)。在参与家庭为基础的预防干预家庭检查的随机对照试验的家庭中，对控制组和干预组的儿童分别进行了关联分析。使用时变效应模型(TVEM)，在对照组中，攻击性的多基因风险与大约 8.50 岁到 9.50 岁的同伴排斥有关，但在干预组中没有关联。后续分析表明，在对照组中，同伴排斥中介了攻击性多基因风险与青少年大麻使用之间的关联。讨论了 rGEs 在儿童中期同伴关系中的作用以及对青少年物质使用预防干预计划的影响。
