Greenberg R S, Rustin E D, Clark W S
Department of Community Health, Emory University School of Medicine, Atlanta, Georgia.
Cancer. 1988 Jan 15;61(2):396-401. doi: 10.1002/1097-0142(19880115)61:2<396::aid-cncr2820610232>3.0.co;2-f.
The risk of second malignancies was evaluated in all men in metropolitan Atlanta who were initially diagnosed as having prostate cancer between January 1, 1975 and December 31, 1982. The cohort of 3675 men was observed through the end of calendar year 1984, yielding a total of 11,916 man-years of observation. Within this population 220 second cancers were diagnosed at sites other than the prostate as compared with 181.2 cancers expected based upon incidence rates for the local general population. Excesses of second malignancies were found in the urethra, kidney and bladder, as well as for melanoma of the skin. The increased risk of second neoplasms was generally greater in men younger than 70. The associated genitourinary malignancies tended to occur within 3 years of the prostatic cancer. Although increased clinical surveillance of this population could explain some of the observed excess of second cancers, these findings also are consistent with multiple cancers arising from shared etiologic factors.
对1975年1月1日至1982年12月31日期间在大都市亚特兰大最初被诊断患有前列腺癌的所有男性的第二原发性恶性肿瘤风险进行了评估。对3675名男性组成的队列进行了观察，直至1984年历年末，共产生了11916人年的观察期。在该人群中，除前列腺外的其他部位诊断出220例第二癌症，而根据当地普通人群的发病率预计为181.2例癌症。在尿道、肾脏和膀胱以及皮肤黑色素瘤中发现了第二原发性恶性肿瘤的超额病例。70岁以下男性的第二肿瘤风险增加通常更大。相关的泌尿生殖系统恶性肿瘤往往在前列腺癌发病后3年内发生。尽管对该人群加强临床监测可以解释观察到的部分第二癌症超额病例，但这些发现也与由共同病因因素引起的多种癌症相一致。
