Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France.
INSERM U1114, Université de Strasbourg, Pôle de Psychiatrie, Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg, France.
Early Interv Psychiatry. 2021 Dec;15(6):1784-1788. doi: 10.1111/eip.13103. Epub 2020 Dec 21.
Psychosis can be preceded by a clinical high risk for psychosis (CHR) and visual anomalies are predictors of transition to psychosis. Visual retinal processing is altered in psychosis, but no study has explored the links between visual symptoms and retinal functions in CHR patients. We report here the case of NR, an antipsychotic-naive young adult with CHR and severe visual symptoms in whom we explored the retinal function.
A flash electroretinogram (fERG) and a pattern electroretinogram (pERG) protocol were conducted and we compared NR results to a group of patients with schizophrenia and a group of healthy controls.
Despites an overlap between the measures of NR and the two groups, visual analyses revealed that NR showed increased b-wave implicit time (rod response) compared to the control group and NR's response was at an intermediate level between two subgroups of schizophrenia patients regarding presence or absence of visual hallucinations.
The relevance of retinal dysfunctions as a marker of vulnerability for psychosis is discussed.
精神病可以先于精神病临床高风险（CHR），并且视觉异常是向精神病过渡的预测指标。精神病患者的视觉视网膜处理发生改变，但尚无研究探讨 CHR 患者的视觉症状与视网膜功能之间的联系。我们在此报告了一个病例，NR 是一个未经抗精神病药物治疗的年轻成年 CHR 患者，伴有严重的视觉症状，我们对此患者的视网膜功能进行了研究。
进行闪光视网膜电图（fERG）和图形视网膜电图（pERG）检测，并将 NR 的结果与一组精神分裂症患者和一组健康对照组进行比较。
尽管 NR 的测量结果与两组之间存在重叠，但视觉分析表明，与对照组相比，NR 的 b 波潜伏期（杆状反应）增加，并且 NR 的反应在存在或不存在幻觉的两个精神分裂症亚组之间处于中间水平。
讨论了视网膜功能障碍作为精神病易感性标志物的相关性。
