Enge I, Nitter-Hauge S, Andrew E, Levorstad K
Radiology. 1977 Nov;125(2):317-22. doi: 10.1148/125.2.317.
Isopaque Coronar and Amipaque (metrizamide) were evaluated in a comparative double-blind study of 30 patients with heart disease undergoing selective coronary angiography. Amipaque alone was also used for 9 additional patients undergoing left ventriculography, aortic root injection, and selective coronary angiography. Amipaque resulted in significantly less of a decrease in diastolic pressure and heart rate, reduced chest pain and heat sensation, and longer coronary contrast transit time. Electrorocardiographic parameters and image quality were equivalent with the 2 agents. No pathological changes were noted in the 9 patients undergoing complete angiocardiographic study.
在一项针对30例患有心脏病并接受选择性冠状动脉造影的患者的比较双盲研究中，对异泛影葡胺冠状动脉造影剂和阿米培克（甲泛葡胺）进行了评估。另外9例接受左心室造影、主动脉根部注射和选择性冠状动脉造影的患者仅使用了阿米培克。阿米培克导致舒张压和心率下降明显较少，胸痛和热感减轻，冠状动脉造影剂通过时间延长。两种造影剂的心电图参数和图像质量相当。在9例接受完整心血管造影研究的患者中未发现病理变化。
