Regenerative Medicine Department, BTI Biotechnology Institute, Vitoria, Spain.
Clinical research, University Institute for Regenerative Medicine and Oral Implantology (UIRMI), Vitoria, Spain.
Platelets. 2021 Feb 17;32(2):174-182. doi: 10.1080/09537104.2020.1856361. Epub 2020 Dec 22.
The application of platelet-rich plasma (PRP) in oral and maxillofacial surgery has been thoroughly studied in the last two decades. Currently, different types of PRP are applied in the clinical practice, being the presence or absence of leukocytes one of the classification criteria. However, there is poor evidence assessing the influence of the PRP composition in their efficacy. In this context, the aim of this narrative review is to compile the existing evidence covering the efficacy of PRP in oral and maxillofacial surgery, starting from a systematic literature search and to qualitatively describe the efficacy outcomes from the composition perspective. According to the results of this review, the application of PRP in oral and maxillofacial surgery is a potential strategy to improve soft- and hard-tissue regeneration, observing differences in the efficacy of PRP depending on its composition and the studied application. -PRP (the absence of leukocytes) has been more consistent in achieving beneficial effects in alveolar ridge preservation, management of post-extraction complications, bone augmentation and temporomandibular joint disorders. For that, the composition and methodology used to prepare the PRP should be a critical point when evaluating the efficacy of PRP.
在过去的二十年中，富血小板血浆（PRP）在口腔颌面外科学中的应用已经得到了深入研究。目前，不同类型的 PRP 应用于临床实践，白细胞的存在与否是分类标准之一。然而，评估 PRP 组成对其疗效的影响的证据不足。在这种情况下，本叙述性综述的目的是从系统文献检索开始，编译涵盖 PRP 在口腔颌面外科学中疗效的现有证据，并从组成角度定性描述疗效结果。根据本综述的结果，PRP 在口腔颌面外科学中的应用是一种改善软组织和硬组织再生的潜在策略，观察到 PRP 的疗效因组成和研究应用的不同而有所不同。-PRP（无白细胞）在牙槽嵴保存、拔牙后并发症管理、骨增量和颞下颌关节紊乱的治疗中更能取得有益效果。因此，在评估 PRP 的疗效时，应将 PRP 的组成和制备方法作为一个关键点。
