Hakala M
Department of Medicine, Päivärinne Hospital, Jokirinne, Finland.
Chest. 1988 Jan;93(1):114-8. doi: 10.1378/chest.93.1.114.
Fifty-seven patients with rheumatoid arthritis (RA) were treated in hospital for diffuse interstitial lung fibrosis. Although interstitial fibrosis (either on the basis of lung function tests or chest roentgenograms or both) is fairly common among patients with RA, according to this study interstitial fibrosis of sufficient extent or severity to warrant hospitalization was rare: incidence of hospitalization due to the lung disease in RA patients was one case per 3,500 patient-years. Eight patients had a largely reversible lung disease associated with drug treatment (gold, D-penicillamine or nitrofurantoin.) The remaining 49 had interstitial fibrosis of unknown cause. Causes for hospitalization were respiratory and general symptoms in 38, but infiltrations on routine chest roentgenographic examinations alone in eleven patients. Forty-five out of the 49 patients had crackles on auscultation. The most typical findings in lung function tests were restriction and a decreased diffusion capacity. These 49 patients showed a poor prognosis, with a median survival of 3.5 years and a five-year survival rate of 39 percent.
57例类风湿关节炎（RA）患者因弥漫性间质性肺纤维化住院治疗。虽然间质性纤维化（基于肺功能测试或胸部X线片或两者）在RA患者中相当常见，但根据本研究，程度或严重程度足以需要住院治疗的间质性纤维化很少见：RA患者因肺部疾病住院的发生率为每3500患者年1例。8例患者有与药物治疗（金制剂、D-青霉胺或呋喃妥因）相关的基本可逆的肺部疾病。其余49例有病因不明的间质性纤维化。住院原因在38例患者中是呼吸系统和全身症状，但仅在11例患者中是常规胸部X线检查时有浸润。49例患者中有45例听诊时有啰音。肺功能测试中最典型的表现是限制性通气和弥散能力下降。这49例患者预后较差，中位生存期为3.5年，五年生存率为39%。
