核酸疫苗在大健康中的关键作用。
The Key Role of Nucleic Acid Vaccines for One Health.
机构信息
Department of Virology and Microbiological Special Diagnostic, Statens Serum Institut, 5 Artillerivej, DK-2300 Copenhagen, Denmark.
ProTherImmune, 3656 Happy Valley Road, Lafayette, CA 94549, USA.
出版信息
Viruses. 2021 Feb 8;13(2):258. doi: 10.3390/v13020258.
Abstract
The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the development of plasmid DNA Nucleic Acid (NA) vaccines, which have been licensed for several veterinary uses, and tested for a number of human diseases, and will explain how an understanding of their immunological and real-world attributes are important for their efficacy, and how they helped pave the way for mRNA vaccines. The review highlights how combining efforts for vaccine development for both animals and humans is crucial for advancing new technologies and for combatting emerging diseases.
摘要
持续的 SARS-CoV-2 大流行凸显了“同一健康”的重要性，即动物和人类之间病原体的相互作用和传播，以及基于基因的疫苗，特别是核酸疫苗的潜在力量。本综述将重点介绍已获得多项兽医用途许可并针对多种人类疾病进行测试的质粒 DNA 核酸 (NA) 疫苗的开发的关键方面，并解释为什么了解它们的免疫和实际属性对其功效很重要，以及它们如何为 mRNA 疫苗铺平道路。该综述强调了为动物和人类的疫苗开发共同努力对于推进新技术和应对新出现的疾病的重要性。
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