HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland; Translational Immunology Research Program and Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland.
Int J Infect Dis. 2021 Mar;104:111-116. doi: 10.1016/j.ijid.2020.12.038. Epub 2020 Dec 19.
The aim was to characterise age- and sex-specific severe acute respiratory syndrome coronavirus disease-2 (SARS-CoV-2) RT-PCR sampling frequency and positivity rate in Greater Helsinki area in Finland during February-June 2020. We also describe the laboratory capacity building for these diagnostics.
Laboratory registry data for altogether 80,791 specimens from 70,517 individuals was analysed. The data included the date of sampling, sex, age and the SARS-CoV-2 RT-PCR test result on specimens collected between 1 February and 15 June 2020.
Altogether, 4057/80,791 (5.0%) of the specimens were positive and 3915/70,517 (5.6%) of the individuals were found positive. In all, 37% of specimens were from male and 67% from female subjects. While the number of positive cases was similar in male and female subjects, the positivity rate was significantly higher in male subjects: 7.5% of male and 4.4% of female subjects tested positive. The highest incidence/100,000 was observed in those aged ≥80 years. The proportion of young adults in positive cases increased in late May 2020. Large dips in testing frequency were observed during every weekend and also during public holidays.
Our data suggest that men pursue SARS-CoV-2 testing less frequently than women. Consequently, a subset of coronavirus disease-2019 infections in men may have gone undetected. People sought testing less frequently on weekends and public holidays, and this may also lead to missing of positive cases. The proportion of young adults in positive cases increased towards the end of the study period, which may suggest their returning back to social behaviour with an increased risk of infection.
本研究旨在描述 2020 年 2 月至 6 月芬兰大赫尔辛基地区年龄和性别特异性严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)实时逆转录聚合酶链反应(RT-PCR)采样频率和阳性率,并描述这些诊断方法的实验室能力建设情况。
分析了 2020 年 2 月 1 日至 6 月 15 日期间共 80791 份来自 70517 人的标本的实验室登记数据。这些数据包括采样日期、性别、年龄以及采集标本的 SARS-CoV-2 RT-PCR 检测结果。
共 4057/80791(5.0%)份标本为阳性,3915/70517(5.6%)名个体为阳性。所有标本中,37%来自男性,67%来自女性。虽然男性和女性的阳性病例数相似,但男性的阳性率显著更高:7.5%的男性和 4.4%的女性检测结果为阳性。≥80 岁人群的发病率/100000 最高。2020 年 5 月下旬,阳性病例中青年成年人的比例增加。每个周末和公共假日检测频率都会大幅下降。
我们的数据表明,男性进行 SARS-CoV-2 检测的频率低于女性。因此,可能有一部分男性的 2019 年冠状病毒病感染未被发现。人们在周末和公共假日较少进行检测,这也可能导致阳性病例的漏检。阳性病例中青年成年人的比例在研究期末增加,这可能表明他们的社交行为恢复,感染风险增加。