Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, PR China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, PR China.
Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China; Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, PR China; Center for Biosafety Research and Strategy, Tianjin University, Tianjin 300072, PR China; Law School of Tianjin University, Tianjin 300072, PR China.
Sci Total Environ. 2021 Mar 20;761:144111. doi: 10.1016/j.scitotenv.2020.144111. Epub 2020 Dec 16.
Environmental pollution caused by heavy metals has received worldwide attentions due to their ubiquity, poor degradability and easy bioaccumulation in host cells. As one potential solution, photosynthetic cyanobacteria have been considered as promising remediation chassis and widely applied in various bioremediation processes of heavy-metals. Meanwhile, deciphering resistant mechanisms and constructing tolerant chassis towards heavy metals could greatly contribute to the successful application of the cyanobacteria-based bioremediation in the future. In this review, first we summarized recent application of cyanobacteria in heavy metals bioremediation using either live or dead cells. Second, resistant mechanisms and strategies for enhancing cyanobacterial bioremediation of heavy metals were discussed. Finally, potential challenges and perspectives for improving bioremediation of heavy metals by cyanobacteria were presented.
由于重金属的普遍性、较差的降解性和易在宿主细胞中生物积累，重金属造成的环境污染受到了全世界的关注。作为一种潜在的解决方案，光合蓝细菌被认为是很有前途的修复底盘，并广泛应用于重金属的各种生物修复过程中。同时，解析抗性机制和构建耐受重金属的底盘将极大地有助于未来基于蓝细菌的生物修复的成功应用。在这篇综述中，首先我们总结了利用活细胞或死细胞的蓝细菌在重金属生物修复中的最新应用。其次，讨论了增强蓝细菌生物修复重金属的抗性机制和策略。最后，提出了通过蓝细菌改善重金属生物修复的潜在挑战和展望。
