Kim Jin Sug, Ko Gang Jee, Kim Yang Gyun, Lee So Young, Lee Dong Young, Jeong Kyung Hwan, Lee Sang Ho
Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul 02453, Korea.
Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea.
J Clin Med. 2020 Dec 18;9(12):4086. doi: 10.3390/jcm9124086.
Endocan, a potential biomarker of endothelial dysfunction, is associated with increased cardiovascular risk. We investigated the utility of plasma endocan for predicting cardiovascular risk in end-stage renal disease (ESRD) patients undergoing hemodialysis. Of the 452 patients in the K-cohort, 354 with available plasma endocan levels were enrolled. The correlation between plasma endocan levels and the clinical characteristics of a study population were analyzed. We divided patients into two groups, according to plasma endocan levels, and investigated the predictive value of endocan for the occurrence of cardiovascular events. In a multiple linear regression analysis, plasma endocan levels were positively correlated with previous cardiovascular events and negatively correlated with body mass index, albumin, and triglyceride. Patients with higher plasma endocan levels experienced more frequent cardiovascular events than those with lower plasma endocan levels (12.9% in the lower group vs. 22.7% in the higher group, = 0.016). Cox proportional hazard models showed that higher plasma endocan levels were an independent predictor of cardiovascular events in ESRD patients on hemodialysis ((hazard ration) HR 1.949, 95% (confidence interval) CI 1.144-3.319, = 0.014). Our results suggest that plasma endocan level might be a useful biomarker for predicting cardiovascular events in ESRD patients on hemodialysis.
内脂素是一种内皮功能障碍的潜在生物标志物，与心血管风险增加有关。我们研究了血浆内脂素在预测接受血液透析的终末期肾病（ESRD）患者心血管风险方面的效用。在K队列的452名患者中，354名有可用血浆内脂素水平的患者被纳入研究。分析了血浆内脂素水平与研究人群临床特征之间的相关性。我们根据血浆内脂素水平将患者分为两组，并研究了内脂素对心血管事件发生的预测价值。在多元线性回归分析中，血浆内脂素水平与既往心血管事件呈正相关，与体重指数、白蛋白和甘油三酯呈负相关。血浆内脂素水平较高的患者比血浆内脂素水平较低的患者经历心血管事件的频率更高（较低组为12.9%，较高组为22.7%，P = 0.016）。Cox比例风险模型显示，较高的血浆内脂素水平是接受血液透析的ESRD患者心血管事件的独立预测因素（风险比HR 1.949，95%置信区间CI 1.144 - 3.319，P = 0.014）。我们的结果表明，血浆内脂素水平可能是预测接受血液透析的ESRD患者心血管事件的有用生物标志物。
