Department of Applied Marine Bioresource Science, National Marine Biodiversity Institute of Korea (MABIK), Seocheon-gun, Chungchungnam-do 33662, Korea.
Growth Engine Research Department, Chungbuk Research Institute (CRI), Chungju, Chungchungbuk-do 28517, Korea.
Toxins (Basel). 2020 Dec 18;12(12):805. doi: 10.3390/toxins12120805.
Dinoflagellates are an important group of phytoplanktons, characterized by two dissimilar flagella and distinctive features of both plants and animals. Dinoflagellate-generated harmful algal blooms (HABs) and associated damage frequently occur in coastal areas, which are concomitant with increasing eutrophication and climate change derived from anthropogenic waste and atmospheric carbon dioxide, respectively. The severe damage and harmful effects of dinoflagellate phycotoxins in the fishing industry have been recognized over the past few decades, and the management and monitoring of HABs have attracted much attention, leaving aside the industrial application of their valuable toxins. Specific modes of action of the organisms' toxins can effectively be utilized for producing beneficial materials, such as Botox and other therapeutic agents. This review aims to explore the potential industrial applications of marine dinoflagellate phycotoxins; furthermore, this review focuses on their modes of action and summarizes the available knowledge on them.
甲藻是一种重要的浮游植物群，其特征是具有两个不同的鞭毛，同时具有植物和动物的特征。由甲藻产生的有害藻类大量繁殖（HABs）以及相关的损害经常发生在沿海地区，这与人为废物导致的富营养化和大气二氧化碳分别导致的气候变化有关。过去几十年中，人们已经认识到甲藻藻毒素对渔业的严重破坏和有害影响，对 HABs 的管理和监测引起了广泛关注，而忽略了其有价值毒素的工业应用。生物体毒素的特定作用模式可有效地用于生产有益材料，例如肉毒杆菌毒素和其他治疗剂。本综述旨在探讨海洋甲藻藻毒素的潜在工业应用；此外，本综述还重点介绍了它们的作用模式，并总结了现有知识。
