Chimbetete Cleophas, Mudzviti Tinashe, Shamu Tinei
Newlands Clinic, Harare, Zimbabwe.
School of Pharmacy, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
South Afr J HIV Med. 2020 Dec 10;21(1):1164. doi: 10.4102/sajhivmed.v21i1.1164. eCollection 2020.
People living with HIV (PLWH) face new challenges such as accelerated ageing and higher rates of comorbidities including cardiovascular, renal and metabolic diseases as they age.
To profile the demographic and clinical characteristics of elderly patients receiving HIV care at Newlands Clinic (NC), Harare, Zimbabwe, as of 01 October 2019.
A cross-sectional analysis was conducted using clinic data. All patients who were 50 years and older on 01 October 2019 were enrolled. Descriptive statistics (medians, interquartile ranges [IQRs] and proportions) were used to describe patient demographic and clinical characteristics.
Out of 6543 patients undergoing care at NC, 1688 (25.8%) were older than 50 years. The median duration of antiretroviral therapy (ART) was 10.9 years (IQR: 7.1-13). Over 90% of all patients had an HIV viral load below 50 copies/mL. Women were more likely than men to be overweight and obese (32% and 25% vs. 18% and 7%, respectively). Hypertension (41.2%), arthritis (19.9%) and chronic kidney disease (11.6%) were common comorbidities differently distributed based on sex. The most common malignancy diagnosed in women was cervical intra-epithelial neoplasia (68% of cancer burden in women) and Kaposi sarcoma was the leading malignancy in men (41% of cancer burden in men). Nearly 20% of patients had at least two chronic non-communicable comorbidities and 5.6% had at least three.
A high burden of comorbidities was observed amongst HIV-positive elderly patients receiving ART. Age-appropriate monitoring protocols must be developed to ensure optimum quality of care for elderly HIV-positive individuals.
随着年龄增长，感染艾滋病毒的人（PLWH）面临新的挑战，如加速衰老以及包括心血管、肾脏和代谢疾病在内的更高的合并症发生率。
描述截至2019年10月1日在津巴布韦哈拉雷纽兰兹诊所（NC）接受艾滋病毒治疗的老年患者的人口统计学和临床特征。
使用诊所数据进行横断面分析。纳入所有在2019年10月1日年龄为50岁及以上的患者。描述性统计（中位数、四分位间距[IQR]和比例）用于描述患者的人口统计学和临床特征。
在NC接受治疗的6543名患者中，1688名（25.8%）年龄超过50岁。抗逆转录病毒疗法（ART）的中位疗程为10.9年（IQR：7.1 - 13）。超过90%的患者艾滋病毒载量低于50拷贝/毫升。女性比男性更易超重和肥胖（分别为32%和25%，而男性为18%和7%）。高血压（41.2%）、关节炎（19.9%）和慢性肾脏病（11.6%）是常见的合并症，且根据性别分布不同。女性中诊断出的最常见恶性肿瘤是宫颈上皮内瘤变（占女性癌症负担的68%），卡波西肉瘤是男性的主要恶性肿瘤（占男性癌症负担的41%）。近20%的患者至少有两种慢性非传染性合并症，5.6%的患者至少有三种。
在接受抗逆转录病毒治疗的艾滋病毒阳性老年患者中观察到较高的合并症负担。必须制定适合年龄的监测方案，以确保为艾滋病毒阳性老年人提供最佳护理质量。
