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人类免疫缺陷病毒感染及高效抗逆转录病毒治疗对心血管系统影响的研究综述

An Outlook on the Impact of HIV Infection and Highly Active Antiretroviral Therapy on the Cardiovascular System - A Review.

作者信息

Antony Ishan, Kannichamy Vishmita, Banerjee Amit, Gandhi Arohi B, Valaiyaduppu Subas Sharathshiva, Hamid Pousette

机构信息

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

出版信息

Cureus. 2020 Nov 18;12(11):e11539. doi: 10.7759/cureus.11539.

DOI:10.7759/cureus.11539
PMID:33354483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7746328/
Abstract

HIV has been related to various cardiovascular pathologies in both adults and children. Highly active antiretroviral therapy (HAART) has been effective in subduing viral replication and improving immunity thereby reducing the effects of HIV both in AIDS and other chronic diseases related to the virus. Complications related to HAART have been reported with metabolic disorders and cardiac effects seen based on the therapy. HIV and HAART have shown to have direct effects on the cardiovascular system, and more public awareness and medical knowledge are required on this subject. This literature review tries to shed some light on the role of HIV and HAART in the cardiovascular manifestations seen in HIV-infected individuals.

摘要

人类免疫缺陷病毒(HIV)与成人和儿童的多种心血管疾病有关。高效抗逆转录病毒疗法(HAART)在抑制病毒复制和提高免疫力方面有效,从而减轻了HIV在艾滋病以及与该病毒相关的其他慢性疾病中的影响。有报道称HAART会引发并发症,出现基于该疗法的代谢紊乱和心脏问题。HIV和HAART已被证明对心血管系统有直接影响,对此主题需要更多公众意识和医学知识。这篇文献综述试图阐明HIV和HAART在HIV感染个体心血管表现中的作用。

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An Outlook on the Impact of HIV Infection and Highly Active Antiretroviral Therapy on the Cardiovascular System - A Review.人类免疫缺陷病毒感染及高效抗逆转录病毒治疗对心血管系统影响的研究综述
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本文引用的文献

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Heart Failure among People with HIV: Evolving Risks, Mechanisms, and Preventive Considerations.HIV 感染者中的心力衰竭:不断变化的风险、机制和预防考虑因素。
Curr HIV/AIDS Rep. 2019 Oct;16(5):371-380. doi: 10.1007/s11904-019-00458-1.
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Heart failure and adverse heart failure outcomes among persons living with HIV in a US tertiary medical center.美国一家三级医疗中心的 HIV 感染者中心力衰竭和心力衰竭不良结局。
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Circulation. 2018 Sep 11;138(11):1100-1112. doi: 10.1161/CIRCULATIONAHA.117.033369.
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Cardiovascular Disease in the Setting of Human Immunodeficiency Virus Infection.人类免疫缺陷病毒感染背景下的心血管疾病
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6
Human immunodeficiency virus-associated heart failure in sub-Saharan Africa: evolution in the epidemiology, pathophysiology, and clinical manifestations in the antiretroviral era.撒哈拉以南非洲地区与人类免疫缺陷病毒相关的心力衰竭:抗逆转录病毒时代的流行病学、病理生理学及临床表现的演变
ESC Heart Fail. 2016 Sep;3(3):158-167. doi: 10.1002/ehf2.12087. Epub 2016 Mar 3.
7
HIV Infection and Primary Prevention of Cardiovascular Disease: Lights and Shadows in the HAART Era.HIV感染与心血管疾病的一级预防:高效抗逆转录病毒治疗时代的光明与阴影
Prog Cardiovasc Dis. 2016 Mar-Apr;58(5):565-76. doi: 10.1016/j.pcad.2016.02.008. Epub 2016 Mar 2.
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HIV, highly active antiretroviral therapy and the heart: a cellular to epidemiological review.人类免疫缺陷病毒、高效抗逆转录病毒疗法与心脏:从细胞层面到流行病学的综述
HIV Med. 2016 Jun;17(6):411-24. doi: 10.1111/hiv.12346. Epub 2015 Nov 26.
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Human Immunodeficiency Virus Infection-Related Heart Disease.人类免疫缺陷病毒感染相关心脏病
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