School of Kinesiology, Shanghai University of Sport, Shanghai, China.
School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Cell Biochem Funct. 2021 Jun;39(4):458-467. doi: 10.1002/cbf.3611. Epub 2020 Dec 23.
Research into the diagnosis, treatment and prevention of childhood-related diseases is the key to reducing their morbidity and mortality. Circular RNAs (circRNAs) play critical roles, both in physiology and pathology, and there is ample evidence to show that they play varying roles in tissue development and gene regulation. Studies on circRNAs in different childhood-related diseases have confirmed their great potential for disease prevention and treatment. These breakthroughs highlight the pathological role of circRNAs in cancers, as well as cardiovascular and hereditary childhood illnesses. In this review, we summarize the role of circRNAs in childhood-related diseases and cancer, and provide an update of the possible diagnostic and therapeutic application of circRNAs.
儿童相关疾病的诊断、治疗和预防研究是降低其发病率和死亡率的关键。环状 RNA（circRNA）在生理和病理中都起着关键作用，有充分的证据表明它们在组织发育和基因调控中发挥不同的作用。不同儿童相关疾病中 circRNAs 的研究证实了它们在疾病预防和治疗方面的巨大潜力。这些突破突出了 circRNAs 在癌症以及心血管和遗传性儿童疾病中的病理作用。在这篇综述中，我们总结了 circRNAs 在儿童相关疾病和癌症中的作用，并提供了 circRNAs 可能的诊断和治疗应用的最新进展。
