Research Institute of Oncology, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk 634009, Russia.
Exp Oncol. 2020 Dec;42(4):263-269. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-4.15414.
The NF-kB1 gene belongs to the family of transcription factors that are involved in the regulation of a wide range of biological reactions. It has been established that NF-kB1 plays an important role in the regulation of immune responses, but more and more studies indicate that this gene is involved in the processes of oncogenesis and DNA repair. The product of this gene regulates the expression of genes involved in the development and progression of cancer. In recent years, numerous studies have been aimed at elucidating the functional consequences of the activation of NF-kB1, as well as its signaling mechanisms. In this regard, NF-kB1 is an interesting therapeutic target for a possible personalized approach in the treatment of cancer. This article provides an overview of modern clinical studies of the NF-kB1 gene, which acts as a predictive and prognostic marker in the treatment of cancer.
NF-kB1 基因属于转录因子家族，参与广泛的生物反应调节。已经证实，NF-kB1 在免疫反应调节中发挥重要作用，但越来越多的研究表明，该基因参与肿瘤发生和 DNA 修复过程。该基因的产物调节参与癌症发展和进展的基因的表达。近年来，许多研究旨在阐明 NF-kB1 的激活及其信号机制的功能后果。在这方面，NF-kB1 是癌症个体化治疗的一个有趣的治疗靶点。本文概述了 NF-kB1 基因的现代临床研究，该基因作为癌症治疗的预测和预后标志物。
