Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Andrologia. 2021 Mar;53(2):e13926. doi: 10.1111/and.13926. Epub 2020 Dec 23.
The purpose of the present study was to investigate the protective potential of Feijoa fruit extract on cadmium chloride (CdCl )-induced testicular injury and pituitary-gonadal axis. Adult male Wistar rats were randomly divided into four groups: (a) control (normal saline, orally), (b) cadmium chloride (0.1 mg/kg, single dose, intraperitoneally), (c) Feijoa fruit extract (400 mg/kg, orally for 30 consecutive days) and (d) CdCl + Feijoa fruit extract. One day after receiving the last medicine, the LH, FSH, prolactin and testosterone concentration were assayed. Also, sperm parameters and tissue structure of the testis were evaluated. Administration of Feijoa fruit extract after CdCl injection in rats ameliorated sperm parameters such as sperm count, morphology, motility and sperm viability, increased levels of LH, FSH, prolactin and testosterone and improved testicular histology. According to the results of this study, it was shown that Feijoa can reduce the destructive side effects of CdCl on testicular tissue and sex hormones of the pituitary-gonadal pathway.
本研究旨在探讨费约果提取物对氯化镉（CdCl ）诱导的睾丸损伤和垂体-性腺轴的保护作用。成年雄性 Wistar 大鼠随机分为四组：（a）对照组（生理盐水，口服）；（b）氯化镉组（0.1mg/kg，单次腹腔注射）；（c）费约果提取物组（400mg/kg，连续 30 天口服）；（d）CdCl + 费约果提取物组。最后一次给药后 1 天，测定 LH、FSH、催乳素和睾酮浓度。同时，评估精子参数和睾丸组织学结构。在大鼠中给予费约果提取物后，可改善精子参数，如精子计数、形态、活力和精子活力，增加 LH、FSH、催乳素和睾酮水平，并改善睾丸组织学。根据这项研究的结果，表明费约果可以减少 CdCl 对睾丸组织和垂体-性腺途径的性激素的破坏性副作用。
