Center for Mental Health, Department of Psychiatry and Psychotherapy, University Hospital of Psychiatry Basel, University of Basel, Basel, Switzerland.
Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Int J Methods Psychiatr Res. 2021 Jun;30(2):e1855. doi: 10.1002/mpr.1855. Epub 2020 Dec 23.
To explore clinical and demographic characteristics impacting patient functioning by determining extent of overlap in factors driving change in Personal and Social Performance (PSP) and other clinical outcomes.
Post-hoc analysis from a single-arm trial of paliperidone extended release in adult patients with nonacute symptomatic schizophrenia. Psychosocial functioning measures: PSP, Clinical Global Impression-Severity (CGI-S), Positive and Negative Syndrome Scale (PANSS), Short-Form 36 (SF-36), treatment satisfaction, sleep quality/daytime drowsiness, and Extrapyramidal Symptoms Rating Scale.
Highest correlations with PSP total score change included PANSS total score change (Spearman's r = 0.607), PANSS general psychopathology change (r = 0.579), and CGI-S change (r = 0.569). A PSP score change of -32 predicted 90% probability of deterioration in CGI-S (score change of ≥1). The power of PSP change to predict PANSS total score change was lower. Linear stepwise regression demonstrated independent relationships for PSP change and: PANSS total change; CGI-S change; SF-36 Mental Component change; treatment satisfaction at endpoint; PSP at baseline; previous psychiatric hospitalizations. R = 0.55 meant that 45% of PSP variation could not be explained by other clinical outcome measures.
Psychosocial functioning improvement is important in schizophrenia. PSP may be valuable for assessing functioning; it encompasses psychosocial and clinical factors not measured by other established assessments.
通过确定影响个人和社会功能（PSP）变化的因素与其他临床结果变化的因素之间的重叠程度，探讨影响患者功能的临床和人口统计学特征。
这是一项帕利哌酮长效制剂治疗成人非急性期症状性精神分裂症的单臂试验的事后分析。心理社会功能测量：PSP、临床总体印象严重度（CGI-S）、阳性和阴性综合征量表（PANSS）、简明 36 健康调查量表（SF-36）、治疗满意度、睡眠质量/白天嗜睡、锥体外系症状评定量表。
与 PSP 总分变化相关性最高的包括 PANSS 总分变化（Spearman's r = 0.607）、PANSS 一般精神病学变化（r = 0.579）和 CGI-S 变化（r = 0.569）。PSP 评分变化-32 预测 CGI-S 恶化的概率为 90%（评分变化≥1）。PSP 变化预测 PANSS 总分变化的能力较低。线性逐步回归显示 PSP 变化与以下因素有独立关系：PANSS 总分变化；CGI-S 变化；SF-36 心理成分变化；终点治疗满意度；PSP 基线值；既往精神科住院治疗。R = 0.55 意味着 45%的 PSP 变化无法用其他临床结果测量来解释。
精神分裂症患者的心理社会功能改善很重要。PSP 可能对评估功能有价值；它包含了其他既定评估未测量的心理社会和临床因素。
