三氟甲磺酸铁(III)和 γ-环糊精催化的吲哚与烯烃的氢胺化反应。

Fe(OTf)- and γ-Cyclodextrin-Catalyzed Hydroamination of Alkenes with Carbazoles.

机构信息

School of Materials Science and Chemical Engineering, Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, P. R. China.

Zhejiang Engineering Research Center for Biomedical Materials, Cixi Institute of BioMedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Cixi 315300, P. R. China.

出版信息

Org Lett. 2021 Jan 15;23(2):449-453. doi: 10.1021/acs.orglett.0c03959. Epub 2020 Dec 23.

DOI:10.1021/acs.orglett.0c03959

PMID:33356323

Abstract

A Fe(OTf)- and γ-cyclodextrin catalyzed hydroamination of alkenes with carbazoles is demonstrated. This biomimetic-catalyst-oriented sustainable and green method could deliver a wide scope of -alkylated carbazoles and -alkylated-carbazole-fused aromatics in up to 97% yield. The salient features of this transformation include simple and benign reaction conditions with no need for a strong base, additive, or the irradiation of light.

摘要

Fe(OTf) 和 γ-环糊精催化烯烃与咔唑的氢胺化反应得到了证明。这种仿生催化剂导向的可持续绿色方法可以提供广泛的 - 烷基化咔唑和 - 烷基化咔唑稠合芳烃，产率高达 97%。这种转化的突出特点包括反应条件简单温和，无需强碱、添加剂或光照。