Palladium-catalyzed amidation of carbazole derivatives hydroamination of isocyanates.

作者信息

Li Meng-Yuan, Chen Peng, Pan Ming-Xia, Hu Hao-Lan, Jiang Yi-Jun

机构信息

Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang 315211, China.

出版信息

Org Biomol Chem. 2024 Jul 31;22(30):6090-6094. doi: 10.1039/d4ob00771a.

DOI:10.1039/d4ob00771a

PMID:39005158

Abstract

The first amidation of carbazoles at the N9 position palladium-catalyzed hydroamination of isocyanates is demonstrated. This simple, general and efficient method could deliver a wide range of carbazole--carboxamides in up to 99% yield. The salient features of this transformation include simple conditions with no need for a strong base, high chemo- and regio-selectivities and good functional group tolerance. In particular, this work-up-free and chromatography-free protocol is time-saving, cost-effective and user-friendly.

摘要