Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Nutritional Health Team (NHT), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Crit Rev Food Sci Nutr. 2022;62(11):3023-3041. doi: 10.1080/10408398.2020.1862048. Epub 2020 Dec 24.
This systematic review and meta-analysis aimed to investigate the effect of zinc supplementation on immune factors in randomized controlled trials.
A comprehensive search was done in PubMed, Scopus, Web of Science, Embase, and Cochrane databases up to December 2020. We used standard and weighted mean differences and 95% confidence intervals for net changes in selected parameters of immune responses. Subgroup analysis was used to find heterogeneity.
Overall, 35 RCTs comprising 1995 participants were eligible for this meta-analysis. There was a significant reduction of circulating CRP (WMD: -32.4; 95% CI: -44.45 to -19.62, p < 0.001), hs-CRP (WMD: -0.95; 95% CI: -1.01 to -0.89, p < 0.001), Neutrophil levels (SMD: -0.46; 95% CI: -0.90 to -0.01, p = 0.043), following zinc supplementation. CD4 level also increased significantly, (WMD: 1.79; 95% CI: 0.57 to 3, p = 0.004). Zinc supplementation had no significant effect on WBC (SMD: -0.66; 95% CI: -1.67 to 0.36, p = 0.204), lymphocyte (WMD: 1.86; 95% CI: -0.86 to 4.58, p = 0.181), monocyte levels (SMD: -0.16; 95% CI: -0.07 to 0.39, p = 0.167), CD3 (SMD: 0.37; 95% CI: -0.49 to 1.22, p = 0.399).
Zinc supplementation decreased the CRP, hs-CRP and TNF-α, IL-6, neutrophil and increased CD3 and CD4 level significantly.
本系统评价和荟萃分析旨在研究随机对照试验中补锌对免疫因子的影响。
我们在 PubMed、Scopus、Web of Science、Embase 和 Cochrane 数据库中进行了全面检索，检索截至 2020 年 12 月。我们使用标准均数差和 95%置信区间来评估所选免疫反应参数的净变化。亚组分析用于寻找异质性。
总体而言，共有 35 项 RCT 符合纳入标准，共纳入 1995 名参与者。补锌后循环 CRP（WMD：-32.4；95%CI：-44.45 至-19.62，p<0.001）、hs-CRP（WMD：-0.95；95%CI：-1.01 至-0.89，p<0.001）、中性粒细胞水平（SMD：-0.46；95%CI：-0.90 至-0.01，p=0.043）显著降低。CD4 水平也显著升高（WMD：1.79；95%CI：0.57 至 3，p=0.004）。补锌对白细胞（SMD：-0.66；95%CI：-1.67 至 0.36，p=0.204）、淋巴细胞（WMD：1.86；95%CI：-0.86 至 4.58，p=0.181）、单核细胞水平（SMD：-0.16；95%CI：-0.07 至 0.39，p=0.167）、CD3（SMD：0.37；95%CI：-0.49 至 1.22，p=0.399）无显著影响。
补锌可降低 CRP、hs-CRP 和 TNF-α、IL-6、中性粒细胞，升高 CD3 和 CD4 水平。
