锌补充对成年人炎症生物标志物和氧化应激的影响：系统评价和随机对照试验的荟萃分析。
Effects of zinc supplementation on inflammatory biomarkers and oxidative stress in adults: A systematic review and meta-analysis of randomized controlled trials.
机构信息
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Trace Elem Med Biol. 2021 Dec;68:126857. doi: 10.1016/j.jtemb.2021.126857. Epub 2021 Sep 20.
BACKGROUND & OBJECTIVE: Current evidence is debatable regarding the feasible effects of zinc supplementation on the inflammation and oxidative stress status of adults. This systematic review and meta-analysis aimed to clarify this inconclusiveness.
MATERIALS AND METHODS
Literature search was conducted via online databases such as PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar until June 2020. The overall effect was presented as the weighted mean difference (WMD) at 95 % confidence interval (CI) in a random-effects meta-analysis model. Publication bias was also assessed using Egger's and Begg's statistics.
RESULTS
In total, 25 clinical trials (n = 1428) were reviewed, which indicated that zinc supplementation significantly affects the concentration of C- reactive protein (WMD: -0.03 mg/l; 95 % CI: -0.06, 0.0; P = 0.029), interlukin-6 (WMD: -3.81 pg/mL; 95 % CI: -6.87, -0.76; P = 0.014), malondialdehyde (WMD: -0.78 μmol/l; 95 % CI: -1.14, -0.42; P < 0.001), and total antioxidant capacity (WMD: 95.96 mmol/l; 95 % CI: 22.47, 169.44; P = 0.010). In addition, a significant between-study heterogeneity and a non-significant increment was reported in nitric oxide (WMD: 1.47 μmol/l; 95 % CI: -2.45, 5.40; P = 0.461) and glutathione (WMD: 34.84 μmol/l; 95 % CI: -5.12, 74.80; P = 0.087).
CONCLUSION
According to the results, zinc supplementation may have beneficial anti-inflammatory and anti-oxidative effects in adults.
背景与目的
目前，关于锌补充对成年人炎症和氧化应激状态的可行影响的证据仍存在争议。本系统评价和荟萃分析旨在阐明这一不确定性。
材料与方法
通过在线数据库（如 PubMed、Scopus、ISI Web of Science、Cochrane Library 和 Google Scholar）进行文献检索，检索时间截至 2020 年 6 月。使用随机效应荟萃分析模型，以加权均数差（WMD）和 95%置信区间（CI）表示总体效应。还使用 Egger 和 Begg 统计评估发表偏倚。
结果
共纳入 25 项临床试验（n=1428），结果表明，锌补充显著影响 C 反应蛋白浓度（WMD：-0.03mg/l；95%CI：-0.06，0.0；P=0.029）、白细胞介素-6（WMD：-3.81pg/mL；95%CI：-6.87，-0.76；P=0.014）、丙二醛（WMD：-0.78μmol/l；95%CI：-1.14，-0.42；P<0.001）和总抗氧化能力（WMD：95.96mmol/l；95%CI：22.47，169.44；P=0.010）。此外，还报道了一氧化氮（WMD：1.47μmol/l；95%CI：-2.45，5.40；P=0.461）和谷胱甘肽（WMD：34.84μmol/l；95%CI：-5.12，74.80；P=0.087）的研究间异质性较大且增量无统计学意义。
结论
根据研究结果，锌补充可能对成年人具有有益的抗炎和抗氧化作用。
Zotero 插件