Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China; Particle and Interfacial Technology Group, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Gent, Belgium.
Particle and Interfacial Technology Group, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Gent, Belgium.
Carbohydr Polym. 2021 Feb 15;254:117446. doi: 10.1016/j.carbpol.2020.117446. Epub 2020 Nov 25.
Probiotics and curcumin can exhibit synergistic biological activities on the basis of a gut-brain axis, but are sensitive to environmental conditions, making it a challenge for their co-utilization. To meet the demand for high efficiency and convenience, both probiotics and curcumin were encapsulated within a propylene glycol alginate-based hydrogel delivery system, which was assembled using an ethanol-induced approach. The composite hydrogel was effective at sustaining the release of curcumin and protecting LGG cells in simulated gastrointestinal tract conditions. Moreover, it could also largely reduce the chemical degradation of curcumin and increase the survival of LGG during light exposure and long-term storage: up to 91.3 % of curcumin and 9.72 log CFU cm remained present throughout 4 weeks of storage. Results in this work demonstrate a low-energy and green approach to assemble a composite hydrogel with remarkable biocompatibility, which is considered as a desired delivery vehicle for co-delivery of probiotics and curcumin.
益生菌和姜黄素可以在肠-脑轴的基础上表现出协同的生物活性，但它们对环境条件敏感，这使得它们的共同利用具有挑战性。为了满足高效率和便利性的需求，益生菌和姜黄素都被封装在基于藻酸钠的丙二醇水凝胶输送系统中，该系统是使用乙醇诱导的方法组装的。该复合水凝胶能有效地维持姜黄素的释放，并在模拟胃肠道条件下保护 LGG 细胞。此外，它还可以大大减少姜黄素的化学降解，并增加 LGG 在光照和长期储存过程中的存活率：在储存 4 周的过程中，仍有高达 91.3%的姜黄素和 9.72 对数 CFU cm 存在。这项工作的结果表明，采用低能量和绿色的方法来组装具有显著生物相容性的复合水凝胶，这被认为是益生菌和姜黄素共同递送的理想载体。
