The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
College of Basic Medical Science of Zhejiang Chinese Medical University, Hangzhou, China.
Clin Ther. 2021 Feb;43(2):e33-e38. doi: 10.1016/j.clinthera.2020.11.016. Epub 2020 Dec 24.
Studies have shown an increased risk for mortality in patients with psoriasis. Furthermore, research has demonstrated an inverse relationship between 25-hydroxyvitamin D (25[OH]D) level and all-cause mortality. This study investigated the association between 25(OH)D level and all-cause mortality in US adults with psoriasis.
Data from NHANES (1999-2014 and mortality data through December 31, 2015) were analyzed. Quartiles of 25(OH)D level were created based on 25(OH)D levels among patients. Cox proportional hazards models were used for estimating hazard ratios (95% CI) for all-cause mortality.
A total of 82,091 participants were enrolled in the NHANES study from 1999 to 2014. Overall, 610 patients with psoriasis were identified in NHANES. The mean (SD) duration of follow-up was 5.61 (3.38) years (3427.92 person-years). The hazard ratio for mortality in the fully adjusted model was 0.12 (95% CI, 0.02-0.60; P = 0.01) in patients with a high 25(OH)D concentration compared to those with 25(OH)D deficiency.
The 25(OH)D concentration was significantly inversely associated with all-cause mortality among these patients with psoriasis. Studies have shown an increased risk for mortality in patients with psoriasis compared to the general population. Vitamin D is not regularly metabolized in patients with psoriasis due to their skin abnormality. Vitamin D supplementation has been associated with a reduced mortality in patients with psoriasis. In practice, attention to vitamin D level is crucial, as is the use of vitamin D supplementation, for improving the health of these patients.
研究表明，银屑病患者的死亡率增加。此外，研究表明 25-羟维生素 D（25[OH]D）水平与全因死亡率呈负相关。本研究调查了美国银屑病患者 25（OH）D 水平与全因死亡率之间的关系。
分析了 NHANES（1999-2014 年）的数据和截至 2015 年 12 月 31 日的死亡率数据。根据患者的 25（OH）D 水平创建了 25（OH）D 水平的四分位距。使用 Cox 比例风险模型估计全因死亡率的危险比（95%CI）。
共有 82091 名参与者参加了 1999 年至 2014 年的 NHANES 研究。总体而言，NHANES 中确定了 610 名银屑病患者。随访的平均（SD）时间为 5.61（3.38）年（3427.92 人年）。在完全调整模型中，与 25（OH）D 缺乏的患者相比，25（OH）D 浓度高的患者死亡的危险比为 0.12（95%CI，0.02-0.60；P=0.01）。
在这些银屑病患者中，25（OH）D 浓度与全因死亡率呈显著负相关。与普通人群相比，银屑病患者的死亡率增加。由于皮肤异常，银屑病患者的维生素 D 不能正常代谢。维生素 D 补充与银屑病患者的死亡率降低有关。在实践中，关注维生素 D 水平至关重要，补充维生素 D 对改善这些患者的健康状况也很重要。
