Department of Family Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Nutrients. 2021 Jan 6;13(1):163. doi: 10.3390/nu13010163.
Vitamin D treatment is effective when applied topically to the skin for plaque-type psoriasis. Oral vitamin D supplementation might be effective as an adjuvant treatment option in psoriasis. This umbrella review aimed to highlight the current knowledge regarding the use of oral vitamin D for treatment of patients with psoriasis. We performed a literature search and identified 107 eligible full-text articles that were relevant to the research interest. Among these, 10 review articles were selected, and data were extracted. A data synthesis showed that only a few studies monitored oral vitamin D efficacy in patients with psoriasis. No studies investigated the optimal dose of systemic vitamin D in psoriasis. However, most studies did not observe side effects for doses within a relatively narrow range (0.25 to 2 μg/day). These results suggest that more large-scale studies are needed to determine the efficacy, optimal dose, and adverse effects of vitamin D administration in patients with psoriasis.
维生素 D 治疗对斑块状银屑病的皮肤局部应用有效。口服维生素 D 补充剂可能是银屑病辅助治疗的有效选择。本综述旨在强调目前关于口服维生素 D 治疗银屑病患者的知识。我们进行了文献检索，确定了 107 篇与研究兴趣相关的合格全文文章。其中，选择了 10 篇综述文章，并提取了数据。数据综合表明，只有少数研究监测了口服维生素 D 在银屑病患者中的疗效。没有研究调查系统性维生素 D 在银屑病中的最佳剂量。然而，大多数研究在相对较窄的剂量范围内（0.25 至 2 μg/天）没有观察到副作用。这些结果表明，需要更多的大规模研究来确定维生素 D 治疗银屑病患者的疗效、最佳剂量和不良反应。
