多区域通讯与信道调制假说。
Multiregional communication and the channel modulation hypothesis.
机构信息
Center for Neural Science, New York University, New York, NY 10003, USA.
Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, VIC 3800, Australia.
出版信息
Curr Opin Neurobiol. 2021 Feb;66:250-257. doi: 10.1016/j.conb.2020.11.016. Epub 2020 Dec 24.
Multiregional communication is important to understanding the brain mechanisms supporting complex behaviors. Work in animals and human subjects shows that multiregional communication plays significant roles in cognitive function and is associated with neurological and neuropsychiatric disorders of brain function. Recent experimental advances enable empirical tests of the mechanisms of multiregional communication. Recent mechanistic insights into brain network function also suggest new therapies to treat disordered brain networks. Here, we discuss how to use the concept of communication channel modulation can help define and constrain what we mean by multiregional communication. We discuss behavioral and neurophysiological evidence for multiregional channels modulation. We then consider the role of causal manipulations and their implications for developing novel therapies based on multiregional communication.
多区域通讯对于理解支持复杂行为的大脑机制非常重要。动物和人类研究表明，多区域通讯在认知功能中起着重要作用，并与大脑功能的神经和神经精神障碍有关。最近的实验进展使对多区域通讯机制的实证测试成为可能。最近对大脑网络功能的机制见解也为治疗紊乱的大脑网络提供了新的治疗方法。在这里，我们讨论如何使用通信信道调制的概念来帮助定义和限制我们对多区域通信的理解。我们讨论了多区域通道调制的行为和神经生理学证据。然后，我们考虑因果操作的作用及其对基于多区域通讯开发新疗法的影响。
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