Lagopati Nefeli, Evangelou Konstantinos, Falaras Polycarpos, Tsilibary Effie-Photini C, Vasileiou Panagiotis V S, Havaki Sofia, Angelopoulou Andriani, Pavlatou Evangelia A, Gorgoulis Vassilis G
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Faculty of Medicine, School of Health Science, National and Kapodistrian University of Athens, 75, Mikras Asias Str., Goudi, GR 11527 Athens, Greece; Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 9, Iroon Polytechniou str., GR 15780 Zografou, Athens, Greece.
Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Faculty of Medicine, School of Health Science, National and Kapodistrian University of Athens, 75, Mikras Asias Str., Goudi, GR 11527 Athens, Greece.
Pharmacol Ther. 2021 Jun;222:107795. doi: 10.1016/j.pharmthera.2020.107795. Epub 2020 Dec 24.
The multivariate condition of cancer disease has been approached in various ways, by the scientific community. Recent studies focus on individualized treatments, minimizing the undesirable consequences of the conventional methods, but the development of an alternative effective therapeutic scheme remains to be held. Nanomedicine could provide a solution, filling this gap, exploiting the unique properties of innovative nanostructured materials. Nanostructured titanium dioxide (TiO) has a variety of applications of daily routine and of advanced technology. Due to its biocompatibility, it has also a great number of biomedical applications. It is now clear that photo-excited TiO nanoparticles, induce generation of pairs of electrons and holes which react with water and oxygen to yield reactive oxygen species (ROS) that have been proven to damage cancer cells, triggering controlled cellular processes. The aim of this review is to provide insights into the field of nanomedicine and particularly into the wide context of TiO-NP-mediated anticancer effect, shedding light on the achievements of nanotechnology and proposing this nanostructured material as a promising anticancer photosensitizer.
科学界已通过多种方式研究癌症疾病的多变量情况。近期研究聚焦于个体化治疗，以尽量减少传统方法的不良后果，但仍有待开发一种有效的替代治疗方案。纳米医学可以提供一种解决方案，填补这一空白，利用创新纳米结构材料的独特特性。纳米结构二氧化钛（TiO₂）在日常生活和先进技术中有多种应用。由于其生物相容性，它也有大量的生物医学应用。现在很清楚，光激发的TiO₂纳米颗粒会诱导产生电子 - 空穴对，这些电子 - 空穴对与水和氧气反应生成活性氧（ROS），已证明这些活性氧会损害癌细胞，触发可控的细胞过程。本综述的目的是深入了解纳米医学领域，特别是TiO₂纳米颗粒介导的抗癌作用的广泛背景，阐明纳米技术的成就，并提出这种纳米结构材料作为一种有前景的抗癌光敏剂。
