Thiomatrix Forschungs- und Beratungs GmbH, Research Center Innsbruck, Trientlgasse 65, 6020, Innsbruck, Austria.
Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Orabona St. 4, 70125 Bari, Italy.
J Control Release. 2021 Feb 10;330:470-482. doi: 10.1016/j.jconrel.2020.12.037. Epub 2020 Dec 23.
This review focuses on the synthesis of hydrogel networks using thiomers such as thiolated hyaluronic acid, chitosan, cyclodextrin, poly(ethylene glycol) and dextran that are cross-linked via their thiol substructures. Thiomers have been widely investigated as matrix of hydrogels due to the high reactivity of these sulfhydryl moieties. They are well known for their in situ gelling properties due to the formation of inter- and intra-chain disulfide bonds. Furthermore, as thiol groups on the polymeric backbone of thiomers cannot only react with each other but also with different other functional groups, several "click" methods such as thiol-ene/yne, Michael type addition and thiol-epoxy reactions have been developed within the last decades to fabricate thiomer hydrogels. These hydrogels are meanwhile used as scaffolds for tissue engineering, regenerative medicine, diagnostics and as matrix for drug and protein delivery.
这篇综述专注于使用硫醇类物质（如巯基化透明质酸、壳聚糖、环糊精、聚乙二醇和葡聚糖）合成水凝胶网络，这些硫醇类物质通过其硫醇结构交联。由于这些巯基部分的高反应性，硫醇类物质已被广泛研究作为水凝胶的基质。由于形成了分子内和分子间的二硫键，它们以其原位凝胶特性而闻名。此外，由于硫醇基团不仅可以在硫醇类物质的聚合物主链上相互反应，还可以与其他不同的官能团反应，因此在过去几十年中已经开发出了几种“点击”方法，如硫醇-烯/炔、迈克尔加成和硫醇-环氧反应，以制备硫醇类物质水凝胶。这些水凝胶同时被用作组织工程、再生医学、诊断的支架，以及药物和蛋白质输送的基质。
